240575

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 839609..840133 Replicon chromosome
Accession NZ_CP094811
Organism Staphylococcus agnetis strain IVB6187

Toxin (Protein)


Gene name mazF Uniprot ID A0A0A8HRS0
Locus tag MUA97_RS03980 Protein ID WP_037567539.1
Coordinates 839780..840133 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A242VEK4
Locus tag MUA97_RS03975 Protein ID WP_060551514.1
Coordinates 839609..839779 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA97_RS03950 (MUA97_03940) 835402..835878 + 477 WP_060551519.1 PH domain-containing protein -
MUA97_RS03955 (MUA97_03945) 835871..837358 + 1488 WP_060551518.1 PH domain-containing protein -
MUA97_RS03960 (MUA97_03950) 837342..837848 + 507 WP_157951749.1 PH domain-containing protein -
MUA97_RS03965 (MUA97_03955) 837920..838270 + 351 WP_060551516.1 holo-ACP synthase -
MUA97_RS03970 (MUA97_03960) 838376..839524 + 1149 WP_262608782.1 alanine racemase -
MUA97_RS03975 (MUA97_03965) 839609..839779 + 171 WP_060551514.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
MUA97_RS03980 (MUA97_03970) 839780..840133 + 354 WP_037567539.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MUA97_RS03985 (MUA97_03975) 840193..841197 + 1005 WP_060551513.1 PP2C family protein-serine/threonine phosphatase -
MUA97_RS03990 (MUA97_03980) 841278..841604 + 327 WP_037567545.1 anti-sigma factor antagonist -
MUA97_RS03995 (MUA97_03985) 841607..842086 + 480 WP_262608783.1 anti-sigma B factor RsbW -
MUA97_RS04000 (MUA97_03990) 842061..842831 + 771 WP_060551512.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13103.33 Da        Isoelectric Point: 10.3729

>T240575 WP_037567539.1 NZ_CP094811:839780-840133 [Staphylococcus agnetis]
MKRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKHKYKLDKDSVILLEQIRT
VDKKRLKEKLTYLSDKKMKEVNAALGISLGLHMNQHK

Download         Length: 354 bp

>T240575 NZ_LT594504:c1372572-1372354 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTTTGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6277.94 Da        Isoelectric Point: 4.0644

>AT240575 WP_060551514.1 NZ_CP094811:839609-839779 [Staphylococcus agnetis]
MSAFYQIRGKSLEQSLKEGYVQMADLNLSLATEAYSVECEACDCNETHLLSNNKDD

Download         Length: 171 bp

>AT240575 NZ_LT594504:c1372972-1372598 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A8HRS0

Antitoxin

Source ID Structure
AlphaFold DB A0A242VEK4

References