Detailed information of TA system TA240571

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 981272..982045
• Replicon: chromosome
• Accession: NZ_CP094809
• Organism: Staphylococcus agnetis strain IVB6197

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: MUA95_RS04745
• Protein ID: WP_164671803.1
• Coordinates: 981890..982045 (+)
• Length: 52 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: -
• Locus tag: MUA95_RS04740
• Protein ID: WP_262626753.1
• Coordinates: 981272..981871 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA95_RS04720 (MUA95_04710)	977576..978298	+	723	WP_262626749.1	amino acid ABC transporter ATP-binding protein	-
MUA95_RS04725 (MUA95_04715)	978470..979597	+	1128	WP_262626750.1	tRNA epoxyqueuosine(34) reductase QueG	-
MUA95_RS04730 (MUA95_04720)	979600..980070	+	471	WP_262626751.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
MUA95_RS04735 (MUA95_04725)	980085..981254	+	1170	WP_262626752.1	N-acetylglucosamine-6-phosphate deacetylase	-
MUA95_RS04740 (MUA95_04730)	981272..981871	+	600	WP_262626753.1	glucosamine-6-phosphate isomerase	Antitoxin
MUA95_RS04745 (MUA95_04735)	981890..982045	+	156	WP_164671803.1	SAS053 family protein	Toxin
MUA95_RS04750 (MUA95_04740)	982204..982605	+	402	WP_262619235.1	hypothetical protein	-
MUA95_RS04755 (MUA95_04745)	982762..984147	+	1386	WP_262626754.1	class II fumarate hydratase	-
MUA95_RS04760 (MUA95_04750)	984169..985695	+	1527	WP_262626755.1	exopolyphosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 6028.39 Da
• Isoelectric Point: 3.9242

>T240571 WP_164671803.1 NZ_CP094809:981890-982045 [Staphylococcus agnetis]
MSDEKHIEHENEMVDNFEDLVQLGKEMEQISETNDQDKVNQSHDPDIRSDQ

Nucleotide

• Length: 156 bp

>T240571 NZ_LT594095:449464-449853 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATAAGTCACAGAACACCGTT
TCTCGCGTCAAAATTTTAAAAATAATTGATTGTCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22445.42 Da
• Isoelectric Point: 5.6315

>AT240571 WP_262626753.1 NZ_CP094809:981272-981871 [Staphylococcus agnetis]
MAMNFKVFKDKDTVAVYAADIIRKQFNNNPTTIAGFHLSEEEAPVLDYLKRNVNDHAVDFSQIHILDYDKQASYFKALGI
PEKQIHEIPEEDEVEKFIEHKAKTKDNKGKLTLQVVSINNKGEFGVPVNNGLKPAREIFVVVTGSDKADVIKKLYEDNGN
TSFIPSSLKTHRMVNVILDEAAAQGLPDDVREYFTSLYA

Nucleotide

• Length: 600 bp

>AT240571 NZ_LT594095:449200-449457 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ACCCTGATTTACTAGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA