Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 844138..844662 Replicon chromosome
Accession NZ_CP094809
Organism Staphylococcus agnetis strain IVB6197

Toxin (Protein)


Gene name mazF Uniprot ID A0A0A8HRS0
Locus tag MUA95_RS03945 Protein ID WP_037567539.1
Coordinates 844309..844662 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A7Z7QEK8
Locus tag MUA95_RS03940 Protein ID WP_037567537.1
Coordinates 844138..844308 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA95_RS03915 (MUA95_03905) 839932..840408 + 477 WP_262619142.1 PH domain-containing protein -
MUA95_RS03920 (MUA95_03910) 840401..841888 + 1488 WP_262626697.1 PH domain-containing protein -
MUA95_RS03925 (MUA95_03915) 841869..842378 + 510 WP_262619144.1 PH domain-containing protein -
MUA95_RS03930 (MUA95_03920) 842449..842799 + 351 WP_060551516.1 holo-ACP synthase -
MUA95_RS03935 (MUA95_03925) 842905..844053 + 1149 WP_262625877.1 alanine racemase -
MUA95_RS03940 (MUA95_03930) 844138..844308 + 171 WP_037567537.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
MUA95_RS03945 (MUA95_03935) 844309..844662 + 354 WP_037567539.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MUA95_RS03950 (MUA95_03940) 844722..845726 + 1005 WP_262626698.1 PP2C family protein-serine/threonine phosphatase -
MUA95_RS03955 (MUA95_03945) 845807..846133 + 327 WP_037567545.1 anti-sigma factor antagonist -
MUA95_RS03960 (MUA95_03950) 846136..846615 + 480 WP_037567547.1 anti-sigma B factor RsbW -
MUA95_RS03965 (MUA95_03955) 846590..847360 + 771 WP_262619147.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13103.33 Da        Isoelectric Point: 10.3729

>T240570 WP_037567539.1 NZ_CP094809:844309-844662 [Staphylococcus agnetis]
MKRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKHKYKLDKDSVILLEQIRT
VDKKRLKEKLTYLSDKKMKEVNAALGISLGLHMNQHK

Download         Length: 354 bp

>T240570 NZ_LT592165:2355-2633 [Neisseria gonorrhoeae]
ATGTACGCGATTTCTTTTGATTTGGTGGTTGCCGATACCGCTCAAAACCATCCGAAAGGCATTTCCCAAGCCTACGCGGA
TATTGGATACACCCTGCGGAAATTCGGCTTTACCCGCATTCAGGGAAGTTTGTACACCTGCCAAAACGAAGATATGGCTA
ACCTGTTTTCAGCCATCAACGAGCTAAAAGCTCTGCCTTGGTTTCCGTCTTCTGTCCGCGATATTCGGGCGTTCCGCATT
GAGCAGTGGTCTGATTTCACAAGTCTTGTGAAGTCTTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6265.89 Da        Isoelectric Point: 4.0644

>AT240570 WP_037567537.1 NZ_CP094809:844138-844308 [Staphylococcus agnetis]
MSAFYQTRGKSLEQSLKEGYVQMADLNLSLATEAYSVECEACDCNETHLLSNNKDD

Download         Length: 171 bp

>AT240570 NZ_LT592165:2170-2355 [Neisseria gonorrhoeae]
ATGCAAACCACTATCCCCACCGGTTCAATCCGCACCTTTGGCGATTACGGCGTGATGTACATCGTCGGCACGCCTGCCGA
ACAGCTTCCGGACGGCGATTGGCTCGTAAATATTGAACTGCCGGAAAGCGGCGAACACACGCAATACAAACTGTCCCACA
TCGTTCAAGACCCAAAGGCTGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A8HRS0

Antitoxin

Source ID Structure
AlphaFold DB A0A7Z7QEK8

References