Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 994195..994968 Replicon chromosome
Accession NZ_CP094808
Organism Staphylococcus agnetis strain IVB6212

Toxin (Protein)


Gene name tsbT Uniprot ID -
Locus tag MUA11_RS04770 Protein ID WP_164671803.1
Coordinates 994813..994968 (+) Length 52 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID -
Locus tag MUA11_RS04765 Protein ID WP_105996312.1
Coordinates 994195..994794 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA11_RS04745 (MUA11_04740) 990499..991221 + 723 WP_262619230.1 amino acid ABC transporter ATP-binding protein -
MUA11_RS04750 (MUA11_04745) 991393..992520 + 1128 WP_105996309.1 tRNA epoxyqueuosine(34) reductase QueG -
MUA11_RS04755 (MUA11_04750) 992523..992993 + 471 WP_262619232.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
MUA11_RS04760 (MUA11_04755) 993008..994177 + 1170 WP_262625937.1 N-acetylglucosamine-6-phosphate deacetylase -
MUA11_RS04765 (MUA11_04760) 994195..994794 + 600 WP_105996312.1 glucosamine-6-phosphate isomerase Antitoxin
MUA11_RS04770 (MUA11_04765) 994813..994968 + 156 WP_164671803.1 SAS053 family protein Toxin
MUA11_RS04775 (MUA11_04770) 995127..995528 + 402 WP_262619235.1 hypothetical protein -
MUA11_RS04780 (MUA11_04775) 995685..997070 + 1386 WP_107391004.1 class II fumarate hydratase -
MUA11_RS04785 (MUA11_04780) 997092..998618 + 1527 WP_105996314.1 exopolyphosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 52 a.a.        Molecular weight: 6028.39 Da        Isoelectric Point: 3.9242

>T240566 WP_164671803.1 NZ_CP094808:994813-994968 [Staphylococcus agnetis]
MSDEKHIEHENEMVDNFEDLVQLGKEMEQISETNDQDKVNQSHDPDIRSDQ

Download         Length: 156 bp

>T240566 NZ_LT592161:768889-769308 [Neisseria gonorrhoeae]
ATGATTTTGCTGGACACGAATGTGATTTCCGAACCTTTGCGCCCACAACCCAATGAACGTGTGGTGGCATGGTTGGATAG
TTTGATATTGGAAGATGTGTATTTGTCTGCCATTACTGTTGCAGAATTGCGTTTGGGTGTGGCGTTGTTGCTCAATGGCA
AGAAAAAGAATGTGCTGCACGAACGTTTGGAACAATCCATTTTGCCTTTATTTGCGGGGCGGATTCTGCCTTTTGATGAA
CCGGTTGCCGCAATCTATGCGCAAATTCGTTCCTATGCCAAAACACATGGCAAAGAGATTGCTGCCGCAGACGGCTATAT
TGCCGCCACTGCAAAACAGCACAGTTTGACAGTTGCTACGCGTGATACCGGCTCATTTTTTGCGGCCGATGTCGCGGTGT
TCAATCCGTGGCACGATTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22431.40 Da        Isoelectric Point: 5.6315

>AT240566 WP_105996312.1 NZ_CP094808:994195-994794 [Staphylococcus agnetis]
MAMNFKVFKDKDTVAVYAADIIRKQFNNNPTTIAGFHLSEEEAPVLDYLKRNVNDHAVDFSQIHILDYDKQASYFKALGV
PEKQIHEIPEEDEVEKFIEHKAKTKDNKGKLTLQVVSINNKGEFGVPVNNGLKPAREIFVVVTGSDKADVIKKLYEDNGN
TSFIPSSLKTHRMVNVILDEAAAQGLPDDVREYFTSLYA

Download         Length: 600 bp

>AT240566 NZ_LT592161:768653-768889 [Neisseria gonorrhoeae]
ATGGCTTCTGTTGTGATTAGAAATTTATCCGAGGCCACGCACAACGCAATCAAATTCCGTGCGCGAGCCGCAGGGCGCAG
TACCGAAGCAGAAATCCGCTTAATTTTGGATAACATCGCCAAAGCACAACAAACTGTACGTTTGGGGTCAATGTTGGCAT
CAATAGGGCAGGAAATCGGAGGTGTTGAGCTGGAAGACGTACGCGGTCGTAATACTGATAACGAGGTTTCTTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References