Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 857249..857773 Replicon chromosome
Accession NZ_CP094808
Organism Staphylococcus agnetis strain IVB6212

Toxin (Protein)


Gene name mazF Uniprot ID A0A0A8HRS0
Locus tag MUA11_RS03970 Protein ID WP_037567539.1
Coordinates 857420..857773 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A7Z7QEK8
Locus tag MUA11_RS03965 Protein ID WP_037567537.1
Coordinates 857249..857419 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA11_RS03940 (MUA11_03935) 853043..853519 + 477 WP_262619142.1 PH domain-containing protein -
MUA11_RS03945 (MUA11_03940) 853512..854999 + 1488 WP_262619143.1 PH domain-containing protein -
MUA11_RS03950 (MUA11_03945) 854980..855489 + 510 WP_262619144.1 PH domain-containing protein -
MUA11_RS03955 (MUA11_03950) 855560..855910 + 351 WP_060551516.1 holo-ACP synthase -
MUA11_RS03960 (MUA11_03955) 856016..857164 + 1149 WP_262625877.1 alanine racemase -
MUA11_RS03965 (MUA11_03960) 857249..857419 + 171 WP_037567537.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
MUA11_RS03970 (MUA11_03965) 857420..857773 + 354 WP_037567539.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MUA11_RS03975 (MUA11_03970) 857833..858837 + 1005 WP_037567543.1 PP2C family protein-serine/threonine phosphatase -
MUA11_RS03980 (MUA11_03975) 858918..859244 + 327 WP_037567545.1 anti-sigma factor antagonist -
MUA11_RS03985 (MUA11_03980) 859247..859726 + 480 WP_037567547.1 anti-sigma B factor RsbW -
MUA11_RS03990 (MUA11_03985) 859701..860471 + 771 WP_262619147.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13103.33 Da        Isoelectric Point: 10.3729

>T240565 WP_037567539.1 NZ_CP094808:857420-857773 [Staphylococcus agnetis]
MKRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKHKYKLDKDSVILLEQIRT
VDKKRLKEKLTYLSDKKMKEVNAALGISLGLHMNQHK

Download         Length: 354 bp

>T240565 NZ_LT592160:2355-2633 [Neisseria gonorrhoeae]
ATGTACGCGATTTCTTTTGATTTGGTGGTTGCCGATACCGCTCAAAACCATCCGAAAGGCATTTCCCAAGCCTACGCGGA
TATTGGATACACCCTGCGGAAATTCGGCTTTACCCGCATTCAGGGAAGTTTGTACACCTGCCAAAACGAAGATATGGCTA
ACCTGTTTTCAGCCATCAACGAGCTAAAAGCTCTGCCTTGGTTTCCGTCTTCTGTCCGCGATATTCGGGCGTTCCGCATT
GAGCAGTGGTCTGATTTCACAAGTCTTGTGAAGTCTTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6265.89 Da        Isoelectric Point: 4.0644

>AT240565 WP_037567537.1 NZ_CP094808:857249-857419 [Staphylococcus agnetis]
MSAFYQTRGKSLEQSLKEGYVQMADLNLSLATEAYSVECEACDCNETHLLSNNKDD

Download         Length: 171 bp

>AT240565 NZ_LT592160:2170-2355 [Neisseria gonorrhoeae]
ATGCAAACCACTATCCCCACCGGTTCAATCCGCACCTTTGGCGATTACGGCGTGATGTACATCGTCGGCACGCCTGCCGA
ACAGCTTCCGGACGGCGATTGGCTCGTAAATATTGAACTGCCGGAAAGCGGCGAACACACGCAATACAAACTGTCCCACA
TCGTTCAAGACCCAAAGGCTGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A8HRS0

Antitoxin

Source ID Structure
AlphaFold DB A0A7Z7QEK8

References