240561

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1000119..1000645 Replicon chromosome
Accession NZ_CP094806
Organism Staphylococcus arlettae strain IVB6234

Toxin (Protein)


Gene name mazF Uniprot ID A0A7V7SNP8
Locus tag MUA71_RS04865 Protein ID WP_002509017.1
Coordinates 1000289..1000645 (+) Length 119 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A7V7VEP5
Locus tag MUA71_RS04860 Protein ID WP_002509016.1
Coordinates 1000119..1000289 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA71_RS04835 (MUA71_04805) 995946..996419 + 474 WP_002509011.1 hypothetical protein -
MUA71_RS04840 (MUA71_04810) 996412..997908 + 1497 WP_142019507.1 PH domain-containing protein -
MUA71_RS04845 (MUA71_04815) 997901..998374 + 474 WP_021459211.1 PH domain-containing protein -
MUA71_RS04850 (MUA71_04820) 998417..998770 + 354 WP_002509014.1 holo-ACP synthase -
MUA71_RS04855 (MUA71_04825) 998882..1000030 + 1149 WP_142019508.1 alanine racemase -
MUA71_RS04860 (MUA71_04830) 1000119..1000289 + 171 WP_002509016.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
MUA71_RS04865 (MUA71_04835) 1000289..1000645 + 357 WP_002509017.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MUA71_RS04870 (MUA71_04840) 1000917..1001918 + 1002 WP_002509018.1 PP2C family protein-serine/threonine phosphatase -
MUA71_RS04875 (MUA71_04845) 1002001..1002327 + 327 WP_002509019.1 anti-sigma factor antagonist -
MUA71_RS04880 (MUA71_04850) 1002329..1002808 + 480 WP_002509020.1 anti-sigma B factor RsbW -
MUA71_RS04885 (MUA71_04855) 1002783..1003553 + 771 WP_103387739.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-108)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13385.57 Da        Isoelectric Point: 10.2885

>T240561 WP_002509017.1 NZ_CP094806:1000289-1000645 [Staphylococcus arlettae]
MRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIRT
LDKKRLKEKLTYLSEDKMKEVNIAIDISLGLHNNRHHK

Download         Length: 357 bp

>T240561 NZ_LT592157:c1539472-1539290 [Neisseria gonorrhoeae]
TTGAATAGCCTAGACGTTATTGCCCTACTCAAACAAGACGGTTGGTATAAAGTTGCACAATCCGGGAGCCATTCGCAATA
TAAGCACCCAACAAAAAAAGGCCGTGTAACCGTGCCGCACCCGAAAAAAGACTTGCCGACAGGTACTGTAAAAAATATCT
ATAAGCAAGCCGGTTTGAAGTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6236.72 Da        Isoelectric Point: 3.8099

>AT240561 WP_002509016.1 NZ_CP094806:1000119-1000289 [Staphylococcus arlettae]
MPSFNQSRNHNIEQSLKEGYSQMADLNLSLAAEAFPFECEACDCNESYISASNTND

Download         Length: 171 bp

>AT240561 NZ_LT592157:c1539188-1538787 [Neisseria gonorrhoeae]
ATGTTTATCCCTGCCGCCCTGCACAAAGACGAACATTCGGCATATGGCGTAACCATCCCCGACCTTCCCGGCTGTTTCTC
TTGCGGCGACACCGTTGAAGAAGCCGTCGCCAACGCCCGTTCTGCCGCCTATATGCATATTGACGGTATGATTGAGGACG
GAGGGTTCAAAAACCTTGCCGTAAGCAGCATTGCCGATTTGAGCCAAGAACCTGATTATCATGGGGCAACATGGGTAATG
ATTGAAATCGACCCTGCAAAAATCAGTCGGCAGCAAATCCGATTCAACGTCAGCTGGCCGCAATACCTTCTTGATAGAGT
GGATGAATATACATCCGCAAATCATGAAACCCGTAGCGGTTTTTTAGCCAAAGCCGCCCTGCTCACCATGAATCAGGCAT
AG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7V7SNP8

Antitoxin

Source ID Structure
AlphaFold DB A0A7V7VEP5

References