Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 989004..989515 Replicon chromosome
Accession NZ_CP094806
Organism Staphylococcus arlettae strain IVB6234

Toxin (Protein)


Gene name TsdT Uniprot ID A0A7V7VCW3
Locus tag MUA71_RS04805 Protein ID WP_002509005.1
Coordinates 989309..989515 (+) Length 69 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A7V7SPC1
Locus tag MUA71_RS04800 Protein ID WP_002509004.1
Coordinates 989004..989297 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA71_RS04780 (MUA71_04750) 984733..985368 + 636 WP_214336814.1 thiamine phosphate synthase -
MUA71_RS04785 (MUA71_04755) 985455..986321 + 867 WP_021459216.1 membrane protein insertase YidC -
MUA71_RS04790 (MUA71_04760) 986642..987289 - 648 WP_262615958.1 HD domain-containing protein -
MUA71_RS04795 (MUA71_04765) 987380..988864 - 1485 WP_262615826.1 cardiolipin synthase -
MUA71_RS04800 (MUA71_04770) 989004..989297 + 294 WP_002509004.1 copper-sensing transcriptional repressor CsoR Antitoxin
MUA71_RS04805 (MUA71_04775) 989309..989515 + 207 WP_002509005.1 hypothetical protein Toxin
MUA71_RS04810 (MUA71_04780) 989685..989825 + 141 WP_002509006.1 Lmo0850 family protein -
MUA71_RS04815 (MUA71_04785) 989872..991068 - 1197 WP_262615830.1 rod shape-determining protein RodA -
MUA71_RS04820 (MUA71_04790) 991307..992377 + 1071 WP_167868164.1 D-alanine--D-alanine ligase -
MUA71_RS04825 (MUA71_04795) 992389..993744 + 1356 WP_204171717.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(24-64)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 7723.91 Da        Isoelectric Point: 5.5509

>T240560 WP_002509005.1 NZ_CP094806:989309-989515 [Staphylococcus arlettae]
MESKVIFLAGLTSYKQQAQLTQKLLNIIGVHQVHVSLEKSIVQITFDTPANLNNIEKEIYDDGYTILF

Download         Length: 207 bp

>T240560 NZ_LT592157:c961912-961493 [Neisseria gonorrhoeae]
ATGATTTTGCTGGACACGAATGTGATTTCCGAACCTTTGCGCCCACAACCCAATGAACGTGTGGTGGCATGGTTGGATAG
TTTGATATTGGAAGATGTGTATTTGTCTGCCATTACTGTTGCAGAATTGCGTTTGGGTGTGGCGTTGTTGCTCAATGGCA
AGAAAAAGAATGTGCTGCACGAACGTTTGGAACAATCCATTTTGCCTTTATTTGCGGGGCGGATTCTGCCTTTTGATGAA
CCGGTTGCCGCAATCTATGCGCAAATTCGTTCCTATGCCAAAACACATGGCAAAGAGATTGCTGCCGCAGACGGCTATAT
TGCCGCCACTGCAAAACAGCACAGTTTGACAGTTGCTACGCGTGATACCGGCTCATTTTTTGCGGCCGATGTCGCGGTGT
TCAATCCGTGGCACGATTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11043.67 Da        Isoelectric Point: 6.8617

>AT240560 WP_002509004.1 NZ_CP094806:989004-989297 [Staphylococcus arlettae]
MTEVDKAHHSTQTKANLKSRLNRIEGQVRAINRMIDEDVYCDDVLTQIRATRSALNSVATKLLDHHMKSCIMDKVNAGEQ
EAAMEELLVTFQKLMKD

Download         Length: 294 bp

>AT240560 NZ_LT592157:c962148-961912 [Neisseria gonorrhoeae]
ATGGCTTCTGTTGTGATTAGAAATTTATCCGAGGCCACGCACAACGCAATCAAATTCCGTGCGCGAGCCGCAGGGCGCAG
TACCGAAGCAGAAATCCGCTTAATTTTGGATAACATCGCCAAAGCACAACAAACTGTACGTTTGGGGTCAATGTTGGCAT
CAATAGGGCAGGAAATCGGAGGTGTTGAGCTGGAAGACGTACGCGGTCGTAATACTGATAACGAGGTTTCTTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7V7VCW3

Antitoxin

Source ID Structure
AlphaFold DB A0A7V7SPC1

References