Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 875404..875930 Replicon chromosome
Accession NZ_CP094803
Organism Staphylococcus arlettae strain IVB6235

Toxin (Protein)


Gene name mazF Uniprot ID A0A7V7SNP8
Locus tag MUA37_RS04165 Protein ID WP_002509017.1
Coordinates 875574..875930 (+) Length 119 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A7V7VEP5
Locus tag MUA37_RS04160 Protein ID WP_002509016.1
Coordinates 875404..875574 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA37_RS04135 (MUA37_04135) 871432..871704 + 273 WP_133173732.1 PH domain-containing protein -
MUA37_RS04140 (MUA37_04140) 871697..873193 + 1497 WP_142019507.1 PH domain-containing protein -
MUA37_RS04145 (MUA37_04145) 873186..873659 + 474 WP_021459211.1 PH domain-containing protein -
MUA37_RS04150 (MUA37_04150) 873702..874055 + 354 WP_002509014.1 holo-ACP synthase -
MUA37_RS04155 (MUA37_04155) 874167..875315 + 1149 WP_142019508.1 alanine racemase -
MUA37_RS04160 (MUA37_04160) 875404..875574 + 171 WP_002509016.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
MUA37_RS04165 (MUA37_04165) 875574..875930 + 357 WP_002509017.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MUA37_RS04170 (MUA37_04170) 876202..877203 + 1002 WP_002509018.1 PP2C family protein-serine/threonine phosphatase -
MUA37_RS04175 (MUA37_04175) 877286..877612 + 327 WP_002509019.1 anti-sigma factor antagonist -
MUA37_RS04180 (MUA37_04180) 877614..878093 + 480 WP_002509020.1 anti-sigma B factor RsbW -
MUA37_RS04185 (MUA37_04185) 878068..878838 + 771 WP_103387739.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-108)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13385.57 Da        Isoelectric Point: 10.2885

>T240558 WP_002509017.1 NZ_CP094803:875574-875930 [Staphylococcus arlettae]
MRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIRT
LDKKRLKEKLTYLSEDKMKEVNIAIDISLGLHNNRHHK

Download         Length: 357 bp

>T240558 NZ_LT592155:1151299-1151481 [Neisseria gonorrhoeae]
TTGAATAGCCTAGACGTTATTGCCCTACTCAAACAAGACGGTTGGTATAAAGTTGCACAATCCGGGAGCCATTCGCAATA
TAAGCACCCAACAAAAAAAGGCCGTGTAACCGTGCCGCACCCGAAAAAAGACTTGCCGACAGGTACTGTAAAAAATATCT
ATAAGCAAGCCGGTTTGAAGTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6236.72 Da        Isoelectric Point: 3.8099

>AT240558 WP_002509016.1 NZ_CP094803:875404-875574 [Staphylococcus arlettae]
MPSFNQSRNHNIEQSLKEGYSQMADLNLSLAAEAFPFECEACDCNESYISASNTND

Download         Length: 171 bp

>AT240558 NZ_LT592155:1151583-1151984 [Neisseria gonorrhoeae]
ATGTTTATCCCTGCCGCCCTGCACAAAGACGAACATTCGGCATATGGCGTAACCATCCCCGACCTTCCCGGCTGTTTCTC
TTGCGGCGACACCGTTGAAGAAGCCGTCGCCAACGCCCGTTCTGCCGCCTATATGCATATTGACGGTATGATTGAGGACG
GAGGGTTCAAAAACCTTGCCGTAAGCAGCATTGCCGATTTGAGCCAAGAACCTGATTATCATGGGGCAACATGGGTAATG
ATTGAAATCGACCCTGCAAAAATCAGTCGGCAGCAAATCCGATTCAACGTCAGCTGGCCGCAATACCTTCTTGATAGAGT
GGATGAATATACATCCGCAAATCATGAAACCCGTAGCGGTTTTTTAGCCAAAGCCGCCCTGCTCACCATGAATCAGGCAT
AG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7V7SNP8

Antitoxin

Source ID Structure
AlphaFold DB A0A7V7VEP5

References