Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 864287..864798 Replicon chromosome
Accession NZ_CP094803
Organism Staphylococcus arlettae strain IVB6235

Toxin (Protein)


Gene name TsdT Uniprot ID A0A7V7VCW3
Locus tag MUA37_RS04105 Protein ID WP_002509005.1
Coordinates 864592..864798 (+) Length 69 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A7V7SPC1
Locus tag MUA37_RS04100 Protein ID WP_002509004.1
Coordinates 864287..864580 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA37_RS04080 (MUA37_04080) 860016..860651 + 636 WP_214336814.1 thiamine phosphate synthase -
MUA37_RS04085 (MUA37_04085) 860738..861604 + 867 WP_021459216.1 membrane protein insertase YidC -
MUA37_RS04090 (MUA37_04090) 861925..862572 - 648 WP_262615958.1 HD domain-containing protein -
MUA37_RS04095 (MUA37_04095) 862663..864147 - 1485 WP_262624844.1 cardiolipin synthase -
MUA37_RS04100 (MUA37_04100) 864287..864580 + 294 WP_002509004.1 copper-sensing transcriptional repressor CsoR Antitoxin
MUA37_RS04105 (MUA37_04105) 864592..864798 + 207 WP_002509005.1 hypothetical protein Toxin
MUA37_RS04110 (MUA37_04110) 864968..865108 + 141 WP_002509006.1 Lmo0850 family protein -
MUA37_RS04115 (MUA37_04115) 865155..866351 - 1197 WP_002509007.1 rod shape-determining protein RodA -
MUA37_RS04120 (MUA37_04120) 866590..867660 + 1071 WP_262624845.1 D-alanine--D-alanine ligase -
MUA37_RS04125 (MUA37_04125) 867672..869027 + 1356 WP_262624846.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(24-64)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 7723.91 Da        Isoelectric Point: 5.5509

>T240557 WP_002509005.1 NZ_CP094803:864592-864798 [Staphylococcus arlettae]
MESKVIFLAGLTSYKQQAQLTQKLLNIIGVHQVHVSLEKSIVQITFDTPANLNNIEKEIYDDGYTILF

Download         Length: 207 bp

>T240557 NZ_LT592155:723566-723985 [Neisseria gonorrhoeae]
ATGATTTTGCTGGACACGAATGTGATTTCCGAACCTTTGCGCCCACAACCCAATGAACGTGTGGTGGCATGGTTGGATAG
TTTGATATTGGAAGATGTGTATTTGTCTGCCATTACTGTTGCAGAATTGCGTTTGGGTGTGGCGTTGTTGCTCAATGGCA
AGAAAAAGAATGTGCTGCACGAACGTTTGGAACAATCCATTTTGCCTTTATTTGCGGGGCGGATTCTGCCTTTTGATGAA
CCGGTTGCCGCAATCTATGCGCAAATTCGTTCCTATGCCAAAACACATGGCAAAGAGATTGCTGCCGCAGACGGCTATAT
TGCCGCCACTGCAAAACAGCACAGTTTGACAGTTGCTACGCGTGATACCGGCTCATTTTTTGCGGCCGATGTCGCGGTGT
TCAATCCGTGGCACGATTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11043.67 Da        Isoelectric Point: 6.8617

>AT240557 WP_002509004.1 NZ_CP094803:864287-864580 [Staphylococcus arlettae]
MTEVDKAHHSTQTKANLKSRLNRIEGQVRAINRMIDEDVYCDDVLTQIRATRSALNSVATKLLDHHMKSCIMDKVNAGEQ
EAAMEELLVTFQKLMKD

Download         Length: 294 bp

>AT240557 NZ_LT592155:723330-723566 [Neisseria gonorrhoeae]
ATGGCTTCTGTTGTGATTAGAAATTTATCCGAGGCCACGCACAACGCAATCAAATTCCGTGCGCGAGCCGCAGGGCGCAG
TACCGAAGCAGAAATCCGCTTAATTTTGGATAACATCGCCAAAGCACAACAAACTGTACGTTTGGGGTCAATGTTGGCAT
CAATAGGGCAGGAAATCGGAGGTGTTGAGCTGGAAGACGTACGCGGTCGTAATACTGATAACGAGGTTTCTTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7V7VCW3

Antitoxin

Source ID Structure
AlphaFold DB A0A7V7SPC1

References