240552

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2197959..2198473 Replicon chromosome
Accession NZ_CP094801
Organism Staphylococcus aureus strain IVB6155

Toxin (Protein)


Gene name TsdT Uniprot ID A0A7U7IDH9
Locus tag MUA25_RS11055 Protein ID WP_000581791.1
Coordinates 2197959..2198168 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag MUA25_RS11060 Protein ID WP_000138934.1
Coordinates 2198180..2198473 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA25_RS11035 (MUA25_11030) 2193848..2194918 - 1071 WP_000159638.1 D-alanine--D-alanine ligase -
MUA25_RS11040 (MUA25_11035) 2195236..2196438 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
MUA25_RS11045 (MUA25_11040) 2196599..2197282 - 684 Protein_2136 transposase -
MUA25_RS11050 (MUA25_11045) 2197694..2197831 - 138 WP_000828354.1 Lmo0850 family protein -
MUA25_RS11055 (MUA25_11050) 2197959..2198168 - 210 WP_000581791.1 heavy metal-associated domain-containing protein Toxin
MUA25_RS11060 (MUA25_11055) 2198180..2198473 - 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
MUA25_RS11065 (MUA25_11060) 2198639..2200123 + 1485 WP_000571560.1 cardiolipin synthase -
MUA25_RS11070 (MUA25_11065) 2200151..2200798 + 648 WP_001187612.1 HD domain-containing protein -
MUA25_RS11075 (MUA25_11070) 2201511..2202383 - 873 WP_000725802.1 membrane protein insertase YidC -
MUA25_RS11080 (MUA25_11075) 2202469..2203110 - 642 WP_045179393.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7826.83 Da        Isoelectric Point: 4.1008

>T240552 WP_000581791.1 NZ_CP094801:c2198168-2197959 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVIINIIDGQVTVAYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T240552 NZ_LT592150:721479-721898 [Neisseria gonorrhoeae]
ATGATTTTGCTGGACACGAATGTGATTTCCGAACCTTTGCGCCCACAACCCAATGAACGTGTGGTGGCATGGTTGGATAG
TTTGATATTGGAAGATGTGTATTTGTCTGCCATTACTGTTGCAGAATTGCGTTTGGGTGTGGCGTTGTTGCTCAATGGCA
AGAAAAAGAATGTGCTGCACGAACGTTTGGAACAATCCATTTTGCCTTTATTTGCGGGGCGGATTCTGCCTTTTGATGAA
CCGGTTGCCGCAATCTATGCGCAAATTCGTTCCTATGCCAAAACACATGGCAAAGAGATTGCTGCCGCAGACGGCTATAT
TGCCGCCACTGCAAAACAGCACAGTTTGACAGTTGCTACGCGTGATACCGGCTCATTTTTTGCGGCCGATGTCGCGGTGT
TCAATCCGTGGCACGATTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT240552 WP_000138934.1 NZ_CP094801:c2198473-2198180 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT240552 NZ_LT592150:721243-721479 [Neisseria gonorrhoeae]
ATGGCTTCTGTTGTGATTAGAAATTTATCCGAGGCCACGCACAACGCAATCAAATTCCGTGCGCGAGCCGCAGGGCGCAG
TACCGAAGCAGAAATCCGCTTAATTTTGGATAACATCGCCAAAGCACAACAAACTGTACGTTTGGGGTCAATGTTGGCAT
CAATAGGGCAGGAAATCGGAGGTGTTGAGCTGGAAGACGTACGCGGTCGTAATACTGATAACGAGGTTTCTTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7IDH9

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References