Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2177223..2177752 Replicon chromosome
Accession NZ_CP094801
Organism Staphylococcus aureus strain IVB6155

Toxin (Protein)


Gene name mazF Uniprot ID Q6GF05
Locus tag MUA25_RS10960 Protein ID WP_000621176.1
Coordinates 2177223..2177585 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag MUA25_RS10965 Protein ID WP_000948331.1
Coordinates 2177582..2177752 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA25_RS10940 (MUA25_10935) 2174201..2174971 - 771 WP_001041107.1 RNA polymerase sigma factor SigB -
MUA25_RS10945 (MUA25_10940) 2174946..2175425 - 480 WP_001190825.1 anti-sigma B factor RsbW -
MUA25_RS10950 (MUA25_10945) 2175427..2175753 - 327 WP_001052491.1 anti-sigma factor antagonist -
MUA25_RS10955 (MUA25_10950) 2175872..2176873 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
MUA25_RS10960 (MUA25_10955) 2177223..2177585 - 363 WP_000621176.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MUA25_RS10965 (MUA25_10960) 2177582..2177752 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
MUA25_RS10970 (MUA25_10965) 2177837..2178985 - 1149 WP_001281140.1 alanine racemase -
MUA25_RS10975 (MUA25_10970) 2179051..2179410 - 360 WP_000581197.1 holo-ACP synthase -
MUA25_RS10980 (MUA25_10975) 2179414..2179905 - 492 WP_001286801.1 PH domain-containing protein -
MUA25_RS10985 (MUA25_10980) 2179898..2181475 - 1578 WP_001294646.1 PH domain-containing protein -
MUA25_RS10990 (MUA25_10985) 2181468..2181947 - 480 WP_001287082.1 hypothetical protein -
MUA25_RS10995 (MUA25_10990) 2182156..2182716 - 561 WP_001092414.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13469.74 Da        Isoelectric Point: 10.1654

>T240551 WP_000621176.1 NZ_CP094801:c2177585-2177223 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVVHQKN

Download         Length: 363 bp

>T240551 NZ_LT592149:2355-2633 [Neisseria gonorrhoeae]
ATGTACGCGATTTCTTTTGATTTGGTGGTTGCCGATACCGCTCAAAACCATCCGAAAGGCATTTCCCAAGCCTACGCGGA
TATTGGATACACCCTGCGGAAATTCGGCTTTACCCGCATTCAGGGAAGTTTGTACACCTGCCAAAACGAAGATATGGCTA
ACCTGTTTTCAGCCATCAACGAGCTAAAAGCTCTGCCTTGGTTTCCGTCTTCTGTCCGCGATATTCGGGCGTTCCGCATT
GAGCAGTGGTCTGATTTCACAAGTCTTGTGAAGTCTTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT240551 WP_000948331.1 NZ_CP094801:c2177752-2177582 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp

>AT240551 NZ_LT592149:2170-2355 [Neisseria gonorrhoeae]
ATGCAAACCACTATCCCCACCGGTTCAATCCGCACCTTTGGCGATTACGGCGTGATGTACATCGTCGGCACGCCTGCCGA
ACAGCTTCCGGACGGCGATTGGCTCGTAAATATTGAACTGCCGGAAAGCGGCGAACACACGCAATACAAACTGTCCCACA
TCGTTCAAGACCCAAAGGCTGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A168PYX0

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References