Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /HTH_19(antitoxin) |
| Location | 1594302..1595090 | Replicon | chromosome |
| Accession | NZ_CP094801 | ||
| Organism | Staphylococcus aureus strain IVB6155 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | - |
| Locus tag | MUA25_RS07805 | Protein ID | WP_045179173.1 |
| Coordinates | 1594629..1595090 (+) | Length | 154 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A0E7YIA0 |
| Locus tag | MUA25_RS07800 | Protein ID | WP_000333630.1 |
| Coordinates | 1594302..1594616 (+) | Length | 105 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MUA25_RS07725 (MUA25_07720) | 1589595..1589915 | - | 321 | WP_000219664.1 | hypothetical protein | - |
| MUA25_RS07730 (MUA25_07725) | 1589916..1590083 | - | 168 | WP_045178556.1 | DUF1270 domain-containing protein | - |
| MUA25_RS07735 (MUA25_07730) | 1590067..1590204 | - | 138 | WP_001568566.1 | hypothetical protein | - |
| MUA25_RS07740 (MUA25_07735) | 1590263..1590475 | + | 213 | WP_000461464.1 | hypothetical protein | - |
| MUA25_RS07745 (MUA25_07740) | 1590490..1590567 | - | 78 | Protein_1520 | hypothetical protein | - |
| MUA25_RS07750 (MUA25_07745) | 1590580..1590843 | - | 264 | WP_001124185.1 | helix-turn-helix domain-containing protein | - |
| MUA25_RS07755 (MUA25_07750) | 1590993..1591091 | - | 99 | Protein_1522 | hypothetical protein | - |
| MUA25_RS07760 (MUA25_07755) | 1591088..1591414 | - | 327 | WP_001025595.1 | hypothetical protein | - |
| MUA25_RS07765 (MUA25_07760) | 1591741..1591980 | - | 240 | WP_001294156.1 | hypothetical protein | - |
| MUA25_RS07770 (MUA25_07765) | 1592040..1592267 | + | 228 | WP_000801108.1 | hypothetical protein | - |
| MUA25_RS07775 (MUA25_07770) | 1592269..1592460 | - | 192 | WP_000389906.1 | hypothetical protein | - |
| MUA25_RS07780 (MUA25_07775) | 1592516..1592881 | + | 366 | WP_001128433.1 | hypothetical protein | - |
| MUA25_RS07785 (MUA25_07780) | 1592850..1593095 | - | 246 | WP_001025401.1 | DUF2829 domain-containing protein | - |
| MUA25_RS07790 (MUA25_07785) | 1593124..1593900 | - | 777 | WP_072519170.1 | Rha family transcriptional regulator | - |
| MUA25_RS07795 (MUA25_07790) | 1593914..1594150 | - | 237 | WP_001121027.1 | helix-turn-helix transcriptional regulator | - |
| MUA25_RS07800 (MUA25_07795) | 1594302..1594616 | + | 315 | WP_000333630.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| MUA25_RS07805 (MUA25_07800) | 1594629..1595090 | + | 462 | WP_045179173.1 | toxin | Toxin |
| MUA25_RS07810 (MUA25_07805) | 1595271..1595462 | + | 192 | WP_252559444.1 | hypothetical protein | - |
| MUA25_RS07815 (MUA25_07810) | 1595459..1596037 | - | 579 | WP_252559441.1 | hypothetical protein | - |
| MUA25_RS07820 (MUA25_07815) | 1596163..1597368 | + | 1206 | WP_262518205.1 | site-specific integrase | - |
| MUA25_RS07825 (MUA25_07820) | 1597411..1599453 | - | 2043 | WP_252559439.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | sak / sea / gnd | 1554973..1624339 | 69366 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 154 a.a. Molecular weight: 18054.43 Da Isoelectric Point: 4.6899
>T240547 WP_045179173.1 NZ_CP094801:1594629-1595090 [Staphylococcus aureus]
MGLYEETLIQHDYIEVREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSIFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEHYKKIYGIGTHYGEYSITFEPLRVFKYKEI
MGLYEETLIQHDYIEVREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSIFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEHYKKIYGIGTHYGEYSITFEPLRVFKYKEI
Download Length: 462 bp
>T240547 NZ_LT591913:2355-2633 [Neisseria gonorrhoeae]
ATGTACGCGATTTCTTTTGATTTGGTGGTTGCCGATACCGCTCAAAACCATCCGAAAGGCATTTCCCAAGCCTACGCGGA
TATTGGATACACCCTGCGGAAATTCGGCTTTACCCGCATTCAGGGAAGTTTGTACACCTGCCAAAACGAAGATATGGCTA
ACCTGTTTTCAGCCATCAACGAGCTAAAAGCTCTGCCTTGGTTTCCGTCTTCTGTCCGCGATATTCGGGCGTTCCGCATT
GAGCAGTGGTCTGATTTCACAAGTCTTGTGAAGTCTTAA
ATGTACGCGATTTCTTTTGATTTGGTGGTTGCCGATACCGCTCAAAACCATCCGAAAGGCATTTCCCAAGCCTACGCGGA
TATTGGATACACCCTGCGGAAATTCGGCTTTACCCGCATTCAGGGAAGTTTGTACACCTGCCAAAACGAAGATATGGCTA
ACCTGTTTTCAGCCATCAACGAGCTAAAAGCTCTGCCTTGGTTTCCGTCTTCTGTCCGCGATATTCGGGCGTTCCGCATT
GAGCAGTGGTCTGATTTCACAAGTCTTGTGAAGTCTTAA
Antitoxin
Download Length: 105 a.a. Molecular weight: 12063.56 Da Isoelectric Point: 6.4736
>AT240547 WP_000333630.1 NZ_CP094801:1594302-1594616 [Staphylococcus aureus]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK
Download Length: 315 bp
>AT240547 NZ_LT591913:2170-2355 [Neisseria gonorrhoeae]
ATGCAAACCACTATCCCCACCGGTTCAATCCGCACCTTTGGCGATTACGGCGTGATGTACATCGTCGGCACGCCTGCCGA
ACAGCTTCCGGACGGCGATTGGCTCGTAAATATTGAACTGCCGGAAAGCGGCGAACACACGCAATACAAACTGTCCCACA
TCGTTCAAGACCCAAAGGCTGCCTAA
ATGCAAACCACTATCCCCACCGGTTCAATCCGCACCTTTGGCGATTACGGCGTGATGTACATCGTCGGCACGCCTGCCGA
ACAGCTTCCGGACGGCGATTGGCTCGTAAATATTGAACTGCCGGAAAGCGGCGAACACACGCAATACAAACTGTCCCACA
TCGTTCAAGACCCAAAGGCTGCCTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|