Detailed information of TA system TA240539

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 402648..403186
• Replicon: chromosome
• Accession: NZ_CP094801
• Organism: Staphylococcus aureus strain IVB6155

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: -
• Locus tag: MUA25_RS01885
• Protein ID: WP_045178601.1
• Coordinates: 402860..403186 (+)
• Length: 109 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: -
• Locus tag: MUA25_RS01880
• Protein ID: WP_045178599.1
• Coordinates: 402648..402857 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA25_RS01840 (MUA25_01840)	397662..398561	-	900	WP_262612385.1	Abi family protein	-
MUA25_RS01845 (MUA25_01845)	398563..399777	-	1215	WP_262612387.1	site-specific integrase	-
MUA25_RS01850 (MUA25_01850)	400056..400685	-	630	WP_231858805.1	XRE family transcriptional regulator	-
MUA25_RS01855 (MUA25_01855)	400708..401232	-	525	Protein_368	SAP domain protein	-
MUA25_RS01860 (MUA25_01860)	401259..401831	-	573	WP_001186980.1	helix-turn-helix transcriptional regulator	-
MUA25_RS01865 (MUA25_01865)	402003..402224	+	222	WP_000560872.1	helix-turn-helix transcriptional regulator	-
MUA25_RS01870 (MUA25_01870)	402225..402497	+	273	WP_000124597.1	helix-turn-helix domain-containing protein	-
MUA25_RS01875 (MUA25_01875)	402509..402655	+	147	WP_000784893.1	hypothetical protein	-
MUA25_RS01880 (MUA25_01880)	402648..402857	+	210	WP_045178599.1	hypothetical protein	Antitoxin
MUA25_RS01885 (MUA25_01885)	402860..403186	+	327	WP_045178601.1	DUF1474 family protein	Toxin
MUA25_RS01890 (MUA25_01890)	403251..404120	+	870	WP_045178602.1	primase alpha helix C-terminal domain-containing protein	-
MUA25_RS01895 (MUA25_01895)	404134..405843	+	1710	Protein_376	DUF927 domain-containing protein	-
MUA25_RS01900 (MUA25_01900)	406154..406534	+	381	WP_000356932.1	hypothetical protein	-
MUA25_RS01905 (MUA25_01905)	406531..407172	+	642	WP_045178603.1	pathogenicity island protein	-
MUA25_RS01910 (MUA25_01910)	407520..407861	+	342	WP_001190600.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	396626..417193	20567

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-100)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 109 a.a.
• Molecular weight: 13093.44 Da
• Isoelectric Point: 4.6496

>T240539 WP_045178601.1 NZ_CP094801:402860-403186 [Staphylococcus aureus]
MNLEINDLFSDLKLLKDRFEDLKDSHGWHFEELYPHEPNHNLNKDELIREGFSYHERRIHNNQMFDLFHLYIEQFDKIIE
KFHEIEKASSENFGEESDDAKNSIKVAE

Nucleotide

• Length: 327 bp

>T240539 NZ_LT591904:c1542469-1542287 [Neisseria gonorrhoeae]
TTGAATAGCCTAGACGTTATTGCCCTACTCAAACAAGACGGTTGGTATAAAGTTGCACAATCCGGGAGCCATTCGCAATA
TAAGCACCCAACAAAAAAAGGCCGTGTAACCGTGCCGCACCCGAAAAAAGACTTGCCGACAGGTACTGTAAAAAATATCT
ATAAGCAAGCCGGTTTGAAGTAA

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8220.25 Da
• Isoelectric Point: 4.3718

>AT240539 WP_045178599.1 NZ_CP094801:402648-402857 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELILKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT240539 NZ_LT591904:c1542185-1541784 [Neisseria gonorrhoeae]
ATGTTTATCCCTGCCGCCCTGCACAAAGACGAACATTCGGCATATGGCGTAACCATCCCCGACCTTCCCGGCTGTTTCTC
TTGCGGCGACACCGTTGAAGAAGCCGTCGCCAACGCCCGTTCTGCCGCCTATATGCATATTGACGGTATGATTGAGGACG
GAGGGTTCAAAAACCTTGCCGTAAGCAGCATTGCCGATTTGAGCCAAGAACCTGATTATCATGGGGCAACATGGGTAATG
ATTGAAATCGACCCTGCAAAAATCAGTCGGCAGCAAATCCGATTCAACGTCAGCTGGCCGCAATACCTTCTTGATAGAGT
GGATGAATATACATCCGCAAATCATGAAACCCGTAGCGGTTTTTTAGCCAAAGCCGCCCTGCTCACCATGAATCAGGCAT
AG