Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2156836..2157350 Replicon chromosome
Accession NZ_CP094800
Organism Staphylococcus aureus strain IVB6158

Toxin (Protein)


Gene name TsdT Uniprot ID -
Locus tag MUA38_RS10715 Protein ID WP_000603099.1
Coordinates 2156836..2157045 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID -
Locus tag MUA38_RS10720 Protein ID WP_000138933.1
Coordinates 2157057..2157350 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA38_RS10695 (2152344) 2152344..2153702 - 1359 WP_000611466.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
MUA38_RS10700 (2153717) 2153717..2154787 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
MUA38_RS10705 (2155105) 2155105..2156307 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
MUA38_RS10710 (2156571) 2156571..2156708 - 138 WP_000828354.1 Lmo0850 family protein -
MUA38_RS10715 (2156836) 2156836..2157045 - 210 WP_000603099.1 heavy metal-associated domain-containing protein Toxin
MUA38_RS10720 (2157057) 2157057..2157350 - 294 WP_000138933.1 copper-sensing transcriptional repressor CsoR Antitoxin
MUA38_RS10725 (2157516) 2157516..2159000 + 1485 WP_250425847.1 cardiolipin synthase -
MUA38_RS10730 (2159028) 2159028..2159690 + 663 WP_001187618.1 HD domain-containing protein -
MUA38_RS10735 (2160247) 2160247..2161113 - 867 WP_064139140.1 membrane protein insertase YidC -
MUA38_RS10740 (2161199) 2161199..2161840 - 642 WP_000483158.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7819.79 Da        Isoelectric Point: 3.9389

>T240535 WP_000603099.1 NZ_CP094800:c2157045-2156836 [Staphylococcus aureus]
MILQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T240535 NZ_LT591901:1942572-1942754 [Neisseria gonorrhoeae]
TTGAATAGCCTAGACGTTATTGCCCTACTCAAACAAGACGGTTGGTATAAAGTTGCACAATCCGGGAGCCATTCGCAATA
TAAGCACCCAACAAAAAAAGGCCGTGTAACCGTGCCGCACCCGAAAAAAGACTTGCCGACAGGTACTGTAAAAAATATCT
ATAAGCAAGCCGGTTTGAAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.81 Da        Isoelectric Point: 6.7122

>AT240535 WP_000138933.1 NZ_CP094800:c2157350-2157057 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNKGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT240535 NZ_LT591901:1942856-1943257 [Neisseria gonorrhoeae]
ATGTTTATCCCTGCCGCCCTGCACAAAGACGAACATTCGGCATATGGCGTAACCATCCCCGACCTTCCCGGCTGTTTCTC
TTGCGGCGACACCGTTGAAGAAGCCGTCGCCAACGCCCGTTCTGCCGCCTATATGCATATTGACGGTATGATTGAGGACG
GAGGGTTCAAAAACCTTGCCGTAAGCAGCATTGCCGATTTGAGCCAAGAACCTGATTATCATGGGGCAACATGGGTAATG
ATTGAAATCGACCCTGCAAAAATCAGTCGGCAGCAAATCCGATTCAACGTCAGCTGGCCGCAATACCTTCTTGATAGAGT
GGATGAATATACATCCGCAAATCATGAAACCCGTAGCGGTTTTTTAGCCAAAGCCGCCCTGCTCACCATGAATCAGGCAT
AG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References