Detailed information of TA system TA240534

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 2137092..2137621
• Replicon: chromosome
• Accession: NZ_CP094800
• Organism: Staphylococcus aureus strain IVB6158

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: MUA38_RS10625
• Protein ID: WP_000621175.1
• Coordinates: 2137092..2137454 (-)
• Length: 121 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: T1YCG8
• Locus tag: MUA38_RS10630
• Protein ID: WP_000948331.1
• Coordinates: 2137451..2137621 (-)
• Length: 57 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA38_RS10605 (2134070)	2134070..2134840	-	771	WP_001041107.1	RNA polymerase sigma factor SigB	-
MUA38_RS10610 (2134815)	2134815..2135294	-	480	WP_001190825.1	anti-sigma B factor RsbW	-
MUA38_RS10615 (2135296)	2135296..2135622	-	327	WP_001052491.1	anti-sigma factor antagonist	-
MUA38_RS10620 (2135741)	2135741..2136742	-	1002	WP_000390829.1	PP2C family protein-serine/threonine phosphatase	-
MUA38_RS10625 (2137092)	2137092..2137454	-	363	WP_000621175.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
MUA38_RS10630 (2137451)	2137451..2137621	-	171	WP_000948331.1	type II toxin-antitoxin system antitoxin MazE	Antitoxin
MUA38_RS10635 (2137706)	2137706..2138854	-	1149	WP_250425843.1	alanine racemase	-
MUA38_RS10640 (2138920)	2138920..2139279	-	360	WP_000581198.1	holo-ACP synthase	-
MUA38_RS10645 (2139283)	2139283..2139774	-	492	WP_001205919.1	PH domain-containing protein	-
MUA38_RS10650 (2139761)	2139761..2141344	-	1584	WP_250425846.1	PH domain-containing protein	-
MUA38_RS10655 (2141337)	2141337..2141816	-	480	WP_001287083.1	hypothetical protein	-
MUA38_RS10660 (2142025)	2142025..2142585	-	561	WP_001092415.1	K(+)-transporting ATPase subunit C	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-110)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 121 a.a.
• Molecular weight: 13441.69 Da
• Isoelectric Point: 10.1654

>T240534 WP_000621175.1 NZ_CP094800:c2137454-2137092 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Nucleotide

• Length: 363 bp

>T240534 NZ_LT591901:c1117300-1116881 [Neisseria gonorrhoeae]
ATGATTTTGCTGGACACGAATGTGATTTCCGAACCTTTGCGCCCACAACCCAATGAACGTGTGGTGGCATGGTTGGATAG
TTTGATATTGGAAGATGTGTATTTGTCTGCCATTACTGTTGCAGAATTGCGTTTGGGTGTGGCGTTGTTGCTCAATGGCA
AGAAAAAGAATGTGCTGCACGAACGTTTGGAACAATCCATTTTGCCTTTATTTGCGGGGCGGATTCTGCCTTTTGATGAA
CCGGTTGCCGCAATCTATGCGCAAATTCGTTCCTATGCCAAAACACATGGCAAAGAGATTGCTGCCGCAGACGGCTATAT
TGCCGCCACTGCAAAACAGCACAGTTTGACAGTTGCTACGCGTGATACCGGCTCATTTTTTGCGGCCGATGTCGCGGTGT
TCAATCCGTGGCACGATTAA

Antitoxin

Protein

• Length: 57 a.a.
• Molecular weight: 6251.78 Da
• Isoelectric Point: 3.8305

>AT240534 WP_000948331.1 NZ_CP094800:c2137621-2137451 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Nucleotide

• Length: 171 bp

>AT240534 NZ_LT591901:c1117536-1117300 [Neisseria gonorrhoeae]
ATGGCTTCTGTTGTGATTAGAAATTTATCCGAGGCCACGCACAACGCAATCAAATTCCGTGCGCGAGCCGCAGGGCGCAG
TACCGAAGCAGAAATCCGCTTAATTTTGGATAACATCGCCAAAGCACAACAAACTGTACGTTTGGGGTCAATGTTGGCAT
CAATAGGGCAGGAAATCGGAGGTGTTGAGCTGGAAGACGTACGCGGTCGTAATACTGATAACGAGGTTTCTTTGTGA

Structures

Antitoxin

• AlphaFold DB: A0A0E0VRZ1