Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1962518..1963294 Replicon chromosome
Accession NZ_CP094800
Organism Staphylococcus aureus strain IVB6158

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag MUA38_RS09585 Protein ID WP_000031108.1
Coordinates 1962518..1962670 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID A0A0D1IYN8
Locus tag MUA38_RS09590 Protein ID WP_001251219.1
Coordinates 1962695..1963294 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA38_RS09570 (1958721) 1958721..1959542 + 822 WP_000669377.1 RluA family pseudouridine synthase -
MUA38_RS09575 (1959993) 1959993..1961378 - 1386 WP_262633469.1 class II fumarate hydratase -
MUA38_RS09580 (1961574) 1961574..1961969 - 396 WP_000901023.1 hypothetical protein -
MUA38_RS09585 (1962518) 1962518..1962670 - 153 WP_000031108.1 SAS053 family protein Toxin
MUA38_RS09590 (1962695) 1962695..1963294 - 600 WP_001251219.1 glucosamine-6-phosphate isomerase Antitoxin
MUA38_RS09595 (1963453) 1963453..1963923 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
MUA38_RS09600 (1963928) 1963928..1965055 - 1128 WP_262633470.1 tRNA epoxyqueuosine(34) reductase QueG -
MUA38_RS09605 (1965206) 1965206..1965928 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
MUA38_RS09610 (1965921) 1965921..1967378 - 1458 WP_103153007.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T240533 WP_000031108.1 NZ_CP094800:c1962670-1962518 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

>T240533 NZ_LT591900:2355-2633 [Neisseria gonorrhoeae]
ATGTACGCGATTTCTTTTGATTTGGTGGTTGCCGATACCGCTCAAAACCATCCGAAAGGCATTTCCCAAGCCTACGCGGA
TATTGGATACACCCTGCGGAAATTCGGCTTTACCCGCATTCAGGGAAGTTTGTACACCTGCCAAAACGAAGATATGGCTA
ACCTGTTTTCAGCCATCAACGAGCTAAAAGCTCTGCCTTGGTTTCCGTCTTCTGTCCGCGATATTCGGGCGTTCCGCATT
GAGCAGTGGTCTGATTTCACAAGTCTTGTGAAGTCTTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22357.50 Da        Isoelectric Point: 5.1445

>AT240533 WP_001251219.1 NZ_CP094800:c1963294-1962695 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNIEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp

>AT240533 NZ_LT591900:2170-2355 [Neisseria gonorrhoeae]
ATGCAAACCACTATCCCCACCGGTTCAATCCGCACCTTTGGCGATTACGGCGTGATGTACATCGTCGGCACGCCTGCCGA
ACAGCTTCCGGACGGCGATTGGCTCGTAAATATTGAACTGCCGGAAAGCGGCGAACACACGCAATACAAACTGTCCCACA
TCGTTCAAGACCCAAAGGCTGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1IYN8

References