Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TscAT/-
Location 896151..896689 Replicon chromosome
Accession NZ_CP094800
Organism Staphylococcus aureus strain IVB6158

Toxin (Protein)


Gene name TscT Uniprot ID -
Locus tag MUA38_RS04335 Protein ID WP_045178618.1
Coordinates 896363..896689 (+) Length 109 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID -
Locus tag MUA38_RS04330 Protein ID WP_045178617.1
Coordinates 896151..896360 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA38_RS04295 (892014) 892014..893234 - 1221 WP_262515151.1 site-specific integrase -
MUA38_RS04300 (893445) 893445..894125 - 681 WP_250406351.1 type II toxin-antitoxin system PemK/MazF family toxin -
MUA38_RS04305 (894265) 894265..894432 - 168 WP_031806878.1 hypothetical protein -
MUA38_RS04310 (894629) 894629..895267 - 639 WP_250425963.1 XRE family transcriptional regulator -
MUA38_RS04315 (895458) 895458..895667 + 210 WP_262633568.1 helix-turn-helix transcriptional regulator -
MUA38_RS04320 (895728) 895728..896000 + 273 WP_250425965.1 helix-turn-helix domain-containing protein -
MUA38_RS04325 (896012) 896012..896158 + 147 WP_250406348.1 pathogenicity island protein -
MUA38_RS04330 (896151) 896151..896360 + 210 WP_045178617.1 hypothetical protein Antitoxin
MUA38_RS04335 (896363) 896363..896689 + 327 WP_045178618.1 DUF1474 family protein Toxin
MUA38_RS04340 (896753) 896753..897622 + 870 WP_262633569.1 primase alpha helix C-terminal domain-containing protein -
MUA38_RS04345 (897639) 897639..899096 + 1458 WP_045178620.1 virulence-associated E family protein -
MUA38_RS04350 (899397) 899397..899759 + 363 WP_045178622.1 hypothetical protein -
MUA38_RS04355 (899761) 899761..900045 + 285 WP_045178623.1 hypothetical protein -
MUA38_RS04360 (900042) 900042..900683 + 642 Protein_847 pathogenicity island protein -
MUA38_RS04365 (901031) 901031..901372 + 342 WP_001190600.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - vWbp 866419..907440 41021


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 13165.42 Da        Isoelectric Point: 4.5527

>T240526 WP_045178618.1 NZ_CP094800:896363-896689 [Staphylococcus aureus]
MNWEINDLFSDLKVLKDRFEDLKDNHGWHFEELYPHEPNHNLNKDELIREGFSYHERRIHNNQMFDLFHLYIEQFDNIIE
KFHEIEKASSENFGEESDDAKNSIKVAE

Download         Length: 327 bp

>T240526 NZ_LT591897:c1043742-1043464 [Neisseria gonorrhoeae]
ATGTACGCGATTTCTTTTGATTTGGTGGTTGCCGATACCGCTCAGAACCATCCGAAAGGCATTTCCCAAGCCTACGCGGA
TATTGGATACACCTTGCGGCAATTCGGCTTTACCCGCGTTCAGGGAGGTTTGTACACCTGCCAAAACGAAGATATGGCTA
ACCTGTTTTCAGCCATCAACGAGCTAAAAGCTCTGCCTTGGTTTCCGTCTTCTGTCCGCGATATTCGGGCGTTCCGCATT
GAGCAGTGGTCTGATTTCACAAGTCTTGTGAAGTCTTAA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8237.34 Da        Isoelectric Point: 4.6311

>AT240526 WP_045178617.1 NZ_CP094800:896151-896360 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLKLSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Download         Length: 210 bp

>AT240526 NZ_LT591897:c1043936-1043742 [Neisseria gonorrhoeae]
ATGCAGACCACAGCAAATACCATCCCCACCGGTTCAATCCGCACCTTTGGCGATTACGGCGTGATGTACATCGTCGGCAC
GCCTGCCGAACAGCTTCCGGACGGCGATTGGCTTGTAAATATCGAGCTGCCGGAAAGCGGCGAACAGACGCAATACAAAC
TGTCCCACATCGTTCAAGACCCAAAGGCTGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References