Detailed information of TA system TA240526

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 896151..896689
• Replicon: chromosome
• Accession: NZ_CP094800
• Organism: Staphylococcus aureus strain IVB6158

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: -
• Locus tag: MUA38_RS04335
• Protein ID: WP_045178618.1
• Coordinates: 896363..896689 (+)
• Length: 109 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: -
• Locus tag: MUA38_RS04330
• Protein ID: WP_045178617.1
• Coordinates: 896151..896360 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA38_RS04295 (892014)	892014..893234	-	1221	WP_262515151.1	site-specific integrase	-
MUA38_RS04300 (893445)	893445..894125	-	681	WP_250406351.1	type II toxin-antitoxin system PemK/MazF family toxin	-
MUA38_RS04305 (894265)	894265..894432	-	168	WP_031806878.1	hypothetical protein	-
MUA38_RS04310 (894629)	894629..895267	-	639	WP_250425963.1	XRE family transcriptional regulator	-
MUA38_RS04315 (895458)	895458..895667	+	210	WP_262633568.1	helix-turn-helix transcriptional regulator	-
MUA38_RS04320 (895728)	895728..896000	+	273	WP_250425965.1	helix-turn-helix domain-containing protein	-
MUA38_RS04325 (896012)	896012..896158	+	147	WP_250406348.1	pathogenicity island protein	-
MUA38_RS04330 (896151)	896151..896360	+	210	WP_045178617.1	hypothetical protein	Antitoxin
MUA38_RS04335 (896363)	896363..896689	+	327	WP_045178618.1	DUF1474 family protein	Toxin
MUA38_RS04340 (896753)	896753..897622	+	870	WP_262633569.1	primase alpha helix C-terminal domain-containing protein	-
MUA38_RS04345 (897639)	897639..899096	+	1458	WP_045178620.1	virulence-associated E family protein	-
MUA38_RS04350 (899397)	899397..899759	+	363	WP_045178622.1	hypothetical protein	-
MUA38_RS04355 (899761)	899761..900045	+	285	WP_045178623.1	hypothetical protein	-
MUA38_RS04360 (900042)	900042..900683	+	642	Protein_847	pathogenicity island protein	-
MUA38_RS04365 (901031)	901031..901372	+	342	WP_001190600.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	vWbp	866419..907440	41021

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-100)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 109 a.a.
• Molecular weight: 13165.42 Da
• Isoelectric Point: 4.5527

>T240526 WP_045178618.1 NZ_CP094800:896363-896689 [Staphylococcus aureus]
MNWEINDLFSDLKVLKDRFEDLKDNHGWHFEELYPHEPNHNLNKDELIREGFSYHERRIHNNQMFDLFHLYIEQFDNIIE
KFHEIEKASSENFGEESDDAKNSIKVAE

Nucleotide

• Length: 327 bp

>T240526 NZ_LT591897:c1043742-1043464 [Neisseria gonorrhoeae]
ATGTACGCGATTTCTTTTGATTTGGTGGTTGCCGATACCGCTCAGAACCATCCGAAAGGCATTTCCCAAGCCTACGCGGA
TATTGGATACACCTTGCGGCAATTCGGCTTTACCCGCGTTCAGGGAGGTTTGTACACCTGCCAAAACGAAGATATGGCTA
ACCTGTTTTCAGCCATCAACGAGCTAAAAGCTCTGCCTTGGTTTCCGTCTTCTGTCCGCGATATTCGGGCGTTCCGCATT
GAGCAGTGGTCTGATTTCACAAGTCTTGTGAAGTCTTAA

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8237.34 Da
• Isoelectric Point: 4.6311

>AT240526 WP_045178617.1 NZ_CP094800:896151-896360 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLKLSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT240526 NZ_LT591897:c1043936-1043742 [Neisseria gonorrhoeae]
ATGCAGACCACAGCAAATACCATCCCCACCGGTTCAATCCGCACCTTTGGCGATTACGGCGTGATGTACATCGTCGGCAC
GCCTGCCGAACAGCTTCCGGACGGCGATTGGCTTGTAAATATCGAGCTGCCGGAAAGCGGCGAACAGACGCAATACAAAC
TGTCCCACATCGTTCAAGACCCAAAGGCTGCCTAA