Detailed information of TA system TA240525

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 879376..879853
• Replicon: chromosome
• Accession: NZ_CP094800
• Organism: Staphylococcus aureus strain IVB6158

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: T1Y7S2
• Locus tag: MUA38_RS04200
• Protein ID: WP_000052076.1
• Coordinates: 879376..879564 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: T1Y6P8
• Locus tag: MUA38_RS04205
• Protein ID: WP_001059690.1
• Coordinates: 879593..879853 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA38_RS04170 (875415)	875415..875885	+	471	WP_000824470.1	hypothetical protein	-
MUA38_RS04175 (876226)	876226..876912	+	687	WP_001804081.1	thermonuclease family protein	-
MUA38_RS04180 (877269)	877269..877469	+	201	WP_001059082.1	cold-shock protein	-
MUA38_RS04185 (877967)	877967..878185	-	219	WP_250425959.1	hypothetical protein	-
MUA38_RS04190 (878247)	878247..878531	-	285	WP_001004401.1	hypothetical protein	-
MUA38_RS04195 (878619)	878619..879188	-	570	WP_001106650.1	lipoprotein N-acylation protein LnsA	-
MUA38_RS04200 (879376)	879376..879564	-	189	WP_000052076.1	hypothetical protein	Toxin
MUA38_RS04205 (879593)	879593..879853	-	261	WP_001059690.1	hypothetical protein	Antitoxin
MUA38_RS04210 (880194)	880194..880397	+	204	WP_000145163.1	sterile alpha motif-like domain-containing protein	-
MUA38_RS04215 (880394)	880394..880630	-	237	WP_000368687.1	hypothetical protein	-
MUA38_RS04220 (880855)	880855..881436	+	582	WP_001140691.1	histidine phosphatase family protein	-
MUA38_RS04225 (881509)	881509..882126	-	618	WP_000255553.1	LysE/ArgO family amino acid transporter	-
MUA38_RS04230 (882282)	882282..882776	-	495	WP_000569881.1	GNAT family N-acetyltransferase	-
MUA38_RS04235 (883175)	883175..883597	-	423	WP_000974454.1	organic hydroperoxide resistance protein	-
MUA38_RS04240 (883745)	883745..884461	+	717	WP_250425960.1	type I 3-dehydroquinate dehydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	vWbp	866419..907440	41021

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-124)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7142.82 Da
• Isoelectric Point: 9.9971

>T240525 WP_000052076.1 NZ_CP094800:c879564-879376 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T240525 NZ_LT591897:c948063-947644 [Neisseria gonorrhoeae]
ATGATTTTGCTGGACACGAATGTGATTTCCGAACCTTTGCGCCCACAACCCAATGAACGTGTGGTGGCATGGTTGGATAG
TTTGATATTGGAAGATGTGTATTTGTCTGCCATTACTGTTGCAGAATTGCGTTTGGGTGTGGCGTTGTTGCTCAATGGCA
AGAAAAAGAATGTGCTGCACGAACGTTTGGAACAATCCATTTTGCCTTTATTTGCGGGGCGGATTCTGCCTTTTGATGAA
CCGGTTGCCGCAATCTATGCGCAAATTCGTTCCTATGCCAAAACACATGGCAAAGAGATTGCTGCCGCAGACGGCTATAT
TGCCGCCACTGCAAAACAGCACAGTTTGACAGTTGCTACGCGTGATACCGGCTCATTTTTTGCGGCCGATGTCGCGGTGT
TCAATCCGTGGCACGATTAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9940.09 Da
• Isoelectric Point: 4.0624

>AT240525 WP_001059690.1 NZ_CP094800:c879853-879593 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Nucleotide

• Length: 261 bp

>AT240525 NZ_LT591897:c948299-948063 [Neisseria gonorrhoeae]
ATGGCTTCTGTTGTGATTAGAAATTTATCCGAGGCCACGCACAACGCAATCAAATTCCGTGCGCGAGCCGCAGGGCGCAG
TACCGAAGCAGAAATCCGCTTAATTTTGGATAACATCGCCAAAGCACAACAAACTGTACGTTTGGGGTCAATGTTGGCAT
CAATAGGGCAGGAAATCGGAGGTGTTGAGCTGGAAGACGTACGCGGTCGTAATACTGATAACGAGGTTTCTTTGTGA

Structures

Toxin

• AlphaFold DB: A0A0E0VP18

Antitoxin

• AlphaFold DB: A0A0E0VN56