240516

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2156833..2157347 Replicon chromosome
Accession NZ_CP094799
Organism Staphylococcus aureus strain IVB6159

Toxin (Protein)


Gene name TsdT Uniprot ID -
Locus tag MUA85_RS10710 Protein ID WP_000603099.1
Coordinates 2156833..2157042 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID -
Locus tag MUA85_RS10715 Protein ID WP_000138933.1
Coordinates 2157054..2157347 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA85_RS10690 (2152341) 2152341..2153699 - 1359 WP_000611466.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
MUA85_RS10695 (2153714) 2153714..2154784 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
MUA85_RS10700 (2155102) 2155102..2156304 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
MUA85_RS10705 (2156568) 2156568..2156705 - 138 WP_000828354.1 Lmo0850 family protein -
MUA85_RS10710 (2156833) 2156833..2157042 - 210 WP_000603099.1 heavy metal-associated domain-containing protein Toxin
MUA85_RS10715 (2157054) 2157054..2157347 - 294 WP_000138933.1 copper-sensing transcriptional repressor CsoR Antitoxin
MUA85_RS10720 (2157513) 2157513..2158997 + 1485 WP_250425847.1 cardiolipin synthase -
MUA85_RS10725 (2159025) 2159025..2159687 + 663 WP_001187618.1 HD domain-containing protein -
MUA85_RS10730 (2160244) 2160244..2161110 - 867 WP_064139140.1 membrane protein insertase YidC -
MUA85_RS10735 (2161196) 2161196..2161837 - 642 WP_000483158.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7819.79 Da        Isoelectric Point: 3.9389

>T240516 WP_000603099.1 NZ_CP094799:c2157042-2156833 [Staphylococcus aureus]
MILQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T240516 NZ_LT578417:c1434238-1433738 [Cyanobium sp. NIES-981]
GTGACCTGGCGGCCGCCGGAGCCGCTGGCCGTCCAGCACCGGCTGGAAGCCTTTGACTGCGGCAAGCCCACACTGAATCA
CTGGCTGTTTCACCACGCCCGCCAGGCGCAGACCAGTGGCTCGGCCCGAACGTTCGTCGTCGCGAACGAGGAGAACCGCG
TTGTCGGCTATTTCAGCCTCACCGTGGGCCAGGTCGACACGGTGAAAGCGCCAGAGCGCATCCGTGCGGGCATGGGGCGA
TTCCCGCTGCCCGTGGTCATCCTGGCCAGGCTCGCCGTGTCACGGGAGAACCATGGACGTGGCCTCGGTGTCGGGATGCT
TCAGGACGCGATCCGTCGGACGCTGGTGATCGCTGACCAGGCCGGAATTCGGGCGATCCTGACCCATCCCATCGACGACG
ATGCGGCCCGCTTCTACACCCGGTTCGGATTCATCACATCGCCGCTGCGCCAGCAGCAACTGCTTCTGCTGCTCAAGGAC
GCGAGGAAGATCCTCCGGTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.81 Da        Isoelectric Point: 6.7122

>AT240516 WP_000138933.1 NZ_CP094799:c2157347-2157054 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNKGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT240516 NZ_LT578417:c1434528-1434235 [Cyanobium sp. NIES-981]
ATGGCTGCCACCGGAGCTTCGCGTCCTGCGCGCTCAGCCCGGCTCGGCCTGCGCGCCACGCCGGAACAGGAAGCCGTGCT
GCGCCGTGCCGCCGAGGTCACCCACAAGTCGCTCACCGACTTCATCCTCGACAGCGCCTGCCTCGCTGCCGAGCAGACGC
TCCTTGATCAGCGCCTGTTCATGGTCTCGGGGTCCCATGCCCAGGCCCTGATCGATCTGCTGGACCGCCCTGAACAGGCC
AACGAAGGGCTCCGTGATCTGTTCACGCGGCAGGCACCCTGGGACGCCCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References