Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TscAT/-
Location 896147..896685 Replicon chromosome
Accession NZ_CP094799
Organism Staphylococcus aureus strain IVB6159

Toxin (Protein)


Gene name TscT Uniprot ID -
Locus tag MUA85_RS04330 Protein ID WP_045178618.1
Coordinates 896359..896685 (+) Length 109 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID -
Locus tag MUA85_RS04325 Protein ID WP_045178617.1
Coordinates 896147..896356 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA85_RS04290 (892010) 892010..893230 - 1221 WP_262515151.1 site-specific integrase -
MUA85_RS04295 (893441) 893441..894121 - 681 WP_250406351.1 type II toxin-antitoxin system PemK/MazF family toxin -
MUA85_RS04300 (894261) 894261..894428 - 168 WP_031806878.1 hypothetical protein -
MUA85_RS04305 (894625) 894625..895263 - 639 WP_250425963.1 XRE family transcriptional regulator -
MUA85_RS04310 (895454) 895454..895663 + 210 WP_262633568.1 helix-turn-helix transcriptional regulator -
MUA85_RS04315 (895724) 895724..895996 + 273 WP_250425965.1 helix-turn-helix domain-containing protein -
MUA85_RS04320 (896008) 896008..896154 + 147 WP_250406348.1 pathogenicity island protein -
MUA85_RS04325 (896147) 896147..896356 + 210 WP_045178617.1 hypothetical protein Antitoxin
MUA85_RS04330 (896359) 896359..896685 + 327 WP_045178618.1 DUF1474 family protein Toxin
MUA85_RS04335 (896749) 896749..897618 + 870 WP_262633569.1 primase alpha helix C-terminal domain-containing protein -
MUA85_RS04340 (897635) 897635..899092 + 1458 WP_045178620.1 virulence-associated E family protein -
MUA85_RS04345 (899393) 899393..899755 + 363 WP_045178622.1 hypothetical protein -
MUA85_RS04350 (899757) 899757..900041 + 285 WP_045178623.1 hypothetical protein -
MUA85_RS04355 (900038) 900038..900680 + 643 Protein_846 pathogenicity island protein -
MUA85_RS04360 (901028) 901028..901369 + 342 WP_001190600.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 874057..907437 33380


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 13165.42 Da        Isoelectric Point: 4.5527

>T240507 WP_045178618.1 NZ_CP094799:896359-896685 [Staphylococcus aureus]
MNWEINDLFSDLKVLKDRFEDLKDNHGWHFEELYPHEPNHNLNKDELIREGFSYHERRIHNNQMFDLFHLYIEQFDNIIE
KFHEIEKASSENFGEESDDAKNSIKVAE

Download         Length: 327 bp

>T240507 NZ_LT571436:c655921-655799 [Neisseria weaveri]
ATGAAAAAATTAGCTTTAATCACAATTGCTACCGTAGCATTGCTAACCGGCTGCAACACCATTGCCGGTGCAGGTGAAGA
TGTCAGCGCAGTAGGACGCGCTGTTACCCATGTTGCCCAATAA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8237.34 Da        Isoelectric Point: 4.6311

>AT240507 WP_045178617.1 NZ_CP094799:896147-896356 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLKLSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Download         Length: 210 bp

>AT240507 NZ_LT571436:c655768-655628 [Neisseria weaveri]
ATGAAAAAATTCGCACTGATCGCTCTTACCGCCGTTTCTTTCTTGGCCGGTTGCAATACCATTGCCGGCGCAGGTAAAGA
TGTCAGCGCTGCAGGTAACGCTGTAACCAACACGGCACAAGACGTTAAATCTGCTATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References