Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 879372..879849 Replicon chromosome
Accession NZ_CP094799
Organism Staphylococcus aureus strain IVB6159

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag MUA85_RS04195 Protein ID WP_000052076.1
Coordinates 879372..879560 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag MUA85_RS04200 Protein ID WP_001059690.1
Coordinates 879589..879849 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA85_RS04165 (875411) 875411..875881 + 471 WP_000824470.1 hypothetical protein -
MUA85_RS04170 (876222) 876222..876908 + 687 WP_001804081.1 thermonuclease family protein -
MUA85_RS04175 (877265) 877265..877465 + 201 WP_001059082.1 cold-shock protein -
MUA85_RS04180 (877963) 877963..878181 - 219 WP_250425959.1 hypothetical protein -
MUA85_RS04185 (878243) 878243..878527 - 285 WP_001004401.1 hypothetical protein -
MUA85_RS04190 (878615) 878615..879184 - 570 WP_001106650.1 lipoprotein N-acylation protein LnsA -
MUA85_RS04195 (879372) 879372..879560 - 189 WP_000052076.1 hypothetical protein Toxin
MUA85_RS04200 (879589) 879589..879849 - 261 WP_001059690.1 hypothetical protein Antitoxin
MUA85_RS04205 (880190) 880190..880393 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
MUA85_RS04210 (880390) 880390..880626 - 237 WP_000368687.1 hypothetical protein -
MUA85_RS04215 (880851) 880851..881432 + 582 WP_001140691.1 histidine phosphatase family protein -
MUA85_RS04220 (881505) 881505..882122 - 618 WP_000255553.1 LysE/ArgO family amino acid transporter -
MUA85_RS04225 (882278) 882278..882772 - 495 WP_000569881.1 GNAT family N-acetyltransferase -
MUA85_RS04230 (883171) 883171..883593 - 423 WP_000974454.1 organic hydroperoxide resistance protein -
MUA85_RS04235 (883741) 883741..884457 + 717 WP_250425960.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 874057..907437 33380


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T240506 WP_000052076.1 NZ_CP094799:c879560-879372 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T240506 NZ_LT556085:c4168411-4168308 [Citrobacter amalonaticus]
GGCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT240506 WP_001059690.1 NZ_CP094799:c879849-879589 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT240506 NZ_LT556085:4168302-4168451 [Citrobacter amalonaticus]
ACAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGT
TGGCATTAATGCAGGCTAAGTCGCCTTGCCTTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTCTGCG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References