Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2196971..2197659 Replicon chromosome
Accession NC_012943
Organism Mycobacterium tuberculosis KZN 1435

Toxin (Protein)


Gene name vapC Uniprot ID P0A653
Locus tag TBMG_RS10505 Protein ID WP_003409958.1
Coordinates 2197240..2197659 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ28
Locus tag TBMG_RS10500 Protein ID WP_003409968.1
Coordinates 2196971..2197231 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TBMG_RS10475 2192462..2193061 - 600 WP_003409989.1 L-lysine exporter -
TBMG_RS10480 2193170..2194081 + 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
TBMG_RS10485 2194166..2194396 - 231 WP_003409980.1 DUF167 domain-containing protein -
TBMG_RS10490 2194511..2195164 + 654 WP_003409976.1 cutinase Cfp21 -
TBMG_RS10495 2195152..2196828 - 1677 WP_003899118.1 PecA family PE domain-processing aspartic protease -
TBMG_RS10500 2196971..2197231 + 261 WP_003409968.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
TBMG_RS10505 2197240..2197659 + 420 WP_003409958.1 type II toxin-antitoxin system VapC family toxin Toxin
TBMG_RS10510 2197884..2198852 + 969 WP_003899116.1 class 1b ribonucleoside-diphosphate reductase subunit beta -
TBMG_RS10515 2199043..2199729 + 687 WP_003409954.1 immunoprotective protein Mpt64 -
TBMG_RS10520 2199908..2201353 + 1446 WP_009938446.1 APC family permease -
TBMG_RS10525 2201316..2202164 - 849 WP_003409942.1 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-125)

Antitoxin

Antitoxin VapB-like

(2-81)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14724.89 Da        Isoelectric Point: 7.9535

>T24050 WP_003409958.1 NC_012943:2197240-2197659 [Mycobacterium tuberculosis KZN 1435]
MIVDTSAVVALVQGERPHATLVAAALAGAHSPVMSAPTVAECLIVLTARHGPVARTIFERLRSEIGLSVSSFTAEHAAAT
QRAFLRYGKGRHRAALNFGDCMTYATAQLGHQPLLAVGNDFPQTDLEFRGVVGYWPGVA

Download         Length: 420 bp

>T24050 NC_012943:2197240-2197659 [Mycobacterium tuberculosis KZN 1435]
ATGATCGTGGACACAAGCGCCGTGGTGGCCCTGGTTCAAGGCGAGCGGCCGCACGCCACCCTGGTCGCGGCCGCCCTGGC
CGGCGCCCATAGCCCCGTCATGTCTGCACCCACCGTCGCCGAATGCCTGATTGTCTTGACCGCCCGTCACGGCCCCGTTG
CGCGCACGATCTTCGAACGACTTCGCAGCGAAATCGGCTTGAGCGTGTCATCTTTCACCGCCGAGCATGCCGCTGCCACG
CAACGAGCCTTTCTGCGATACGGCAAGGGGCGCCACCGCGCGGCTCTCAACTTCGGAGACTGTATGACGTACGCGACCGC
CCAGCTGGGCCACCAACCACTGCTGGCCGTCGGCAACGACTTCCCGCAAACCGACCTTGAGTTCCGCGGCGTCGTCGGCT
ACTGGCCAGGCGTCGCGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9528.88 Da        Isoelectric Point: 5.1007

>AT24050 WP_003409968.1 NC_012943:2196971-2197231 [Mycobacterium tuberculosis KZN 1435]
VALNIKDPEVDRLAAELADRLHTSKTAAIRHALSAQLAFLESRAGDREAQLLDILRTEIWPLLADRSPITKLEREQILGY
DPATGV

Download         Length: 261 bp

>AT24050 NC_012943:2196971-2197231 [Mycobacterium tuberculosis KZN 1435]
GTGGCGCTGAATATCAAAGACCCTGAGGTAGACCGACTAGCCGCCGAACTCGCTGACCGGCTGCACACCAGCAAGACTGC
CGCCATCCGGCATGCCCTGTCTGCCCAGCTGGCGTTTTTGGAGTCGCGCGCCGGCGACCGTGAGGCACAACTTCTCGACA
TCTTGCGTACCGAAATCTGGCCCCTGCTTGCCGACCGCTCCCCCATCACCAAGCTCGAGCGCGAACAAATCCTCGGCTAC
GACCCCGCAACCGGAGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829C4H9

Antitoxin

Source ID Structure
AlphaFold DB A0A829C483

References