Detailed information of TA system TA240492

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 2060572..2061086
• Replicon: chromosome
• Accession: NZ_CP094797
• Organism: Staphylococcus aureus strain IVB6163

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: -
• Locus tag: MUA16_RS10230
• Protein ID: WP_262515866.1
• Coordinates: 2060572..2060874 (-)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: -
• Locus tag: MUA16_RS10235
• Protein ID: WP_262515867.1
• Coordinates: 2060871..2061086 (-)
• Length: 72 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA16_RS10200 (2055722)	2055722..2056300	-	579	WP_262515861.1	pathogenicity island protein	-
MUA16_RS10205 (2056312)	2056312..2056653	-	342	WP_262516299.1	pathogenicity island protein	-
MUA16_RS10210 (2057000)	2057000..2057641	-	642	WP_262515863.1	pathogenicity island protein	-
MUA16_RS10215 (2057643)	2057643..2057915	-	273	WP_111762498.1	pathogenicity island protein	-
MUA16_RS10220 (2057902)	2057902..2058705	-	804	WP_000148373.1	bifunctional DNA primase/polymerase	-
MUA16_RS10225 (2058881)	2058881..2060497	-	1617	WP_262515864.1	phage resistance protein	-
MUA16_RS10230 (2060572)	2060572..2060874	-	303	WP_262515866.1	DUF1474 family protein	Toxin
MUA16_RS10235 (2060871)	2060871..2061086	-	216	WP_262515867.1	pathogenicity island protein	Antitoxin
MUA16_RS10240 (2061079)	2061079..2061225	-	147	WP_000784893.1	hypothetical protein	-
MUA16_RS10245 (2061222)	2061222..2061539	-	318	WP_000481969.1	helix-turn-helix domain-containing protein	-
MUA16_RS10250 (2061555)	2061555..2061755	-	201	WP_111762499.1	helix-turn-helix transcriptional regulator	-
MUA16_RS10255 (2061918)	2061918..2062595	+	678	WP_111762500.1	helix-turn-helix transcriptional regulator	-
MUA16_RS10260 (2062612)	2062612..2063784	+	1173	WP_111762501.1	tyrosine-type recombinase/integrase	-
MUA16_RS10265 (2063853)	2063853..2065469	-	1617	WP_262515869.1	chaperonin GroEL	-
MUA16_RS10270 (2065545)	2065545..2065829	-	285	WP_000917289.1	co-chaperone GroES	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	groEL	2043265..2065829	22564

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-100)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 12181.39 Da
• Isoelectric Point: 4.6906

>T240492 WP_262515866.1 NZ_CP094797:c2060874-2060572 [Staphylococcus aureus]
MNWEINDLFSDLKVLKDRFEDLKDNHGWHFDNFYPHEPNHVLNKTEAIKEGLSYHERRIHNNQMFDLFHLYIEQFDKIIE
KFHEIEKASSENFGEESDDA

Nucleotide

• Length: 303 bp

>T240492 NZ_LT556084:4195478-4195696 [Citrobacter amalonaticus]
ATGTCCGATAAACCATTAACTAAAACTGATTATTTGATGCGCTTGCGACGCTGTCAGACAATTGACACACTTGAACGCGT
GATTGAGAAAAATAAATATGAATTATCTGACAATGAATTGGCTGTATTTTACTCAGCCGCCGATCACCGTCTTGCAGAAT
TGACGATGAATAAACTTTACGACAAGATCCCCTCCTCCGTCTGGAAATTCATTCGTTAA

Antitoxin

Protein

• Length: 72 a.a.
• Molecular weight: 8494.58 Da
• Isoelectric Point: 4.5099

>AT240492 WP_262515867.1 NZ_CP094797:c2061086-2060871 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGEQK

Nucleotide

• Length: 216 bp

>AT240492 NZ_LT556084:4195076-4195450 [Citrobacter amalonaticus]
ATGGATGAATACTCACCCAAAAGACATGATATAGCGCAGCTTAAATTTCTTTGTGAAACGCTTTATCACGACTGTCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTTCAACTCAACGAACTGATAGAGC
ATATTGCAACCTTCGCACTTAATTATAAAATTAAGTATAATGAGGATAATAAGCTGATTGAGCAGATTGATGAATATCTG
GACGACACATTTATGTTGTTCAGCAGTTATGGCATTAATGCGCAGGATCTGCAGAAATGGCGGAAATCAGGTAATCGCTT
GTTCCGCTGCTTTGTGAATGCCACCAGAGCTAACCCTGTTAGTTTGTCTTGTTAA