Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1946457..1947233 Replicon chromosome
Accession NZ_CP094797
Organism Staphylococcus aureus strain IVB6163

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag MUA16_RS09515 Protein ID WP_000031108.1
Coordinates 1946457..1946609 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID A0A0D1IYN8
Locus tag MUA16_RS09520 Protein ID WP_001251219.1
Coordinates 1946634..1947233 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA16_RS09500 (1942603) 1942603..1943424 + 822 WP_000669380.1 RluA family pseudouridine synthase -
MUA16_RS09505 (1943880) 1943880..1945265 - 1386 WP_000116227.1 class II fumarate hydratase -
MUA16_RS09510 (1945461) 1945461..1945856 - 396 WP_000901019.1 hypothetical protein -
MUA16_RS09515 (1946457) 1946457..1946609 - 153 WP_000031108.1 SAS053 family protein Toxin
MUA16_RS09520 (1946634) 1946634..1947233 - 600 WP_001251219.1 glucosamine-6-phosphate isomerase Antitoxin
MUA16_RS09525 (1947392) 1947392..1947862 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
MUA16_RS09530 (1947867) 1947867..1948994 - 1128 WP_000379980.1 tRNA epoxyqueuosine(34) reductase QueG -
MUA16_RS09535 (1949145) 1949145..1949867 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
MUA16_RS09540 (1949860) 1949860..1951317 - 1458 WP_262519346.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T240491 WP_000031108.1 NZ_CP094797:c1946609-1946457 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

>T240491 NZ_LT556084:c3592294-3592037 [Citrobacter amalonaticus]
ATGAATTTATCCCGTCAGGAACAACGTACCTTACACGTTCTCGCCAAAGGTGGACGTATTGCGCACGTCCGCGATGCGTC
AGGCCGCGTCACCGCCGTTGAATGCTACAGCCGCGAAGGGCTGCTGCTCGCCGACTGTACACTTGCCGTCTTCAAAAAAC
TCAAAACCAAAAAGCTGATCAAATCCGTCAATGGTCAGCCGTACCGCATTAATACCACCGGGCTGAACAACGTGCGTGCT
CAGCCAGATAACCGCTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22357.50 Da        Isoelectric Point: 5.1445

>AT240491 WP_001251219.1 NZ_CP094797:c1947233-1946634 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNIEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp

>AT240491 NZ_LT556084:c3592026-3591475 [Citrobacter amalonaticus]
ATGACAACACGCAACTTCACTATTCATATTACCGATGAAAGTGATACCAACGACATCCGGGAAGTCGAAACCCGCGCCTT
TGGCTACAGTAAAGAGGCCTGCCTGGTGGCTTCTTTGCTCGAGGACGACACTGCGCGTCCAACGTTATCGTTGCTGGCCA
GACAGGAAGGTAACGCCGTCGGGCATATCCTGTTTACCCGGGCGACATTCAAAGGAGAAATGGATTCCCCTCTGATGCAT
ATCCTTGCTCCCCTGGCGGTCATCCCTGAATACCAGGGGAGGGGCGTGGGCGGATTATTGATTCGTACCGGTATAGAACA
CTTACGCTCGATGGGATGCCAGTGCGTTTTTGTTCTCGGTCATGCCACTTACTATCCGCGACATGGATTTGAACCCTGTG
CAGGAGACAAAGGCTTTCCCGCGCCTTACCCCATTGCGGAGGAACATAAGGCCTGCTGGATGATGCAGTCCCTCTCCGCA
CAACCCTTTGATCGTGCCGGCGACATCCAATGTGCGCAGGCCTTAATGAAACCGGAGCACTGGCGTGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1IYN8

References