Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mbcAT/RES-TIGR02293
Location 2189435..2190333 Replicon chromosome
Accession NC_012943
Organism Mycobacterium tuberculosis KZN 1435

Toxin (Protein)


Gene name mbcT Uniprot ID P64908
Locus tag TBMG_RS10460 Protein ID WP_003410001.1
Coordinates 2189773..2190333 (+) Length 187 a.a.

Antitoxin (Protein)


Gene name mbcA Uniprot ID P64910
Locus tag TBMG_RS10455 Protein ID WP_003410003.1
Coordinates 2189435..2189776 (+) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TBMG_RS10420 2185088..2185444 + 357 WP_003410018.1 Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR -
TBMG_RS10425 2185497..2185769 + 273 WP_003410017.1 DUF1490 family protein -
TBMG_RS10430 2185766..2188081 + 2316 WP_003899120.1 cation transporter ATPase CptG -
TBMG_RS10435 2188181..2188429 + 249 WP_003410014.1 ribbon-helix-helix protein, CopG family -
TBMG_RS10440 2188423..2188767 + 345 WP_003410010.1 type II toxin-antitoxin system toxin endoribonuclease MazF6 -
TBMG_RS10445 2188856..2189191 + 336 WP_003410009.1 dehydrogenase -
TBMG_RS10450 2189092..2189349 - 258 WP_003410006.1 hypothetical protein -
TBMG_RS10455 2189435..2189776 + 342 WP_003410003.1 DUF2384 domain-containing protein Antitoxin
TBMG_RS10460 2189773..2190333 + 561 WP_003410001.1 RES family NAD+ phosphorylase Toxin
TBMG_RS10465 2190853..2191392 - 540 WP_003900446.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37) -
TBMG_RS10470 2191618..2192046 - 429 WP_003906713.1 cellulose-binding protein -
TBMG_RS10475 2192462..2193061 - 600 WP_003409989.1 L-lysine exporter -
TBMG_RS10480 2193170..2194081 + 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
TBMG_RS10485 2194166..2194396 - 231 WP_003409980.1 DUF167 domain-containing protein -
TBMG_RS10490 2194511..2195164 + 654 WP_003409976.1 cutinase Cfp21 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(25-148)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(69-110)


Sequences

Toxin        


Download         Length: 187 a.a.        Molecular weight: 20248.70 Da        Isoelectric Point: 4.5091

>T24049 WP_003410001.1 NC_012943:2189773-2190333 [Mycobacterium tuberculosis KZN 1435]
VSDALDEGLVQRIDARGTIEWSETCYRYTGAHRDALSGEGARRFGGRWNPPLLFPAIYLADSAQACMVEVERAAQAASTT
AEKMLEAAYRLHTIDVTDLAVLDLTTPQAREAVGLENDDIYGDDWSGCQAVGHAAWFLHMQGVLVPAAGGVGLVVTAYEQ
RTRPGQLQLRQSVDLTPALYQELRAT

Download         Length: 561 bp

>T24049 NC_012943:2189773-2190333 [Mycobacterium tuberculosis KZN 1435]
GTGAGCGATGCCCTCGATGAAGGGCTCGTCCAGCGTATCGACGCACGCGGAACAATTGAGTGGTCGGAAACGTGCTACCG
GTATACCGGCGCGCACCGTGACGCCTTGTCCGGTGAGGGCGCGCGCAGATTCGGAGGCAGGTGGAATCCGCCGCTGCTCT
TTCCGGCGATCTATCTTGCTGATTCCGCCCAAGCCTGCATGGTTGAGGTGGAACGGGCGGCGCAAGCGGCTTCAACGACC
GCAGAGAAGATGCTCGAGGCGGCCTACCGACTACACACGATCGACGTCACGGACCTGGCCGTCCTCGATCTGACAACCCC
GCAAGCTCGGGAAGCCGTGGGGCTCGAGAACGACGACATCTATGGCGACGACTGGTCAGGGTGCCAGGCGGTCGGACATG
CGGCCTGGTTCTTGCACATGCAAGGTGTCCTCGTGCCGGCGGCGGGCGGTGTCGGCCTCGTTGTCACCGCGTATGAACAG
CGAACTCGGCCGGGCCAACTACAACTGCGACAAAGCGTCGATCTGACGCCTGCTCTTTACCAAGAACTTCGAGCCACGTA
G

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12488.33 Da        Isoelectric Point: 4.8359

>AT24049 WP_003410003.1 NC_012943:2189435-2189776 [Mycobacterium tuberculosis KZN 1435]
MGVNVLASTVSGAIERLGLTYEEVGDIVDASPRSVARWTAGQVVPQRLNKQRLIELAYVADALAEVLPRDQANVWMFSPN
RLLEHRKPADLVRDGEYQRVLALIDAMAEGVFV

Download         Length: 342 bp

>AT24049 NC_012943:2189435-2189776 [Mycobacterium tuberculosis KZN 1435]
ATGGGAGTAAATGTGCTCGCCTCGACCGTGTCGGGTGCGATCGAGCGCTTGGGATTGACCTACGAGGAAGTCGGTGACAT
CGTCGATGCCTCGCCGCGTTCCGTGGCGCGATGGACCGCAGGTCAGGTGGTTCCCCAACGCCTCAACAAGCAACGACTTA
TCGAGCTGGCCTATGTCGCCGACGCCCTCGCGGAAGTGCTGCCGCGTGACCAGGCGAACGTGTGGATGTTTTCGCCGAAT
CGGTTACTGGAACACCGCAAGCCTGCCGACCTCGTGCGAGACGGCGAGTACCAACGCGTGTTGGCGCTCATCGACGCGAT
GGCGGAGGGAGTGTTCGTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FKG

Antitoxin

Source ID Structure
PDB 6FKG
AlphaFold DB A0A7U4FAE4

References