Detailed information of TA system TA240488

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 891167..891705
• Replicon: chromosome
• Accession: NZ_CP094797
• Organism: Staphylococcus aureus strain IVB6163

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: -
• Locus tag: MUA16_RS04370
• Protein ID: WP_045178618.1
• Coordinates: 891379..891705 (+)
• Length: 109 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: -
• Locus tag: MUA16_RS04365
• Protein ID: WP_045178617.1
• Coordinates: 891167..891376 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA16_RS04330 (887030)	887030..888250	-	1221	WP_262515151.1	site-specific integrase	-
MUA16_RS04335 (888461)	888461..889141	-	681	WP_262519410.1	type II toxin-antitoxin system PemK/MazF family toxin	-
MUA16_RS04340 (889281)	889281..889448	-	168	WP_031806878.1	hypothetical protein	-
MUA16_RS04345 (889645)	889645..890283	-	639	WP_250406350.1	XRE family transcriptional regulator	-
MUA16_RS04350 (890474)	890474..890728	+	255	WP_250425964.1	helix-turn-helix transcriptional regulator	-
MUA16_RS04355 (890744)	890744..891016	+	273	WP_250425965.1	helix-turn-helix domain-containing protein	-
MUA16_RS04360 (891028)	891028..891174	+	147	WP_262519411.1	pathogenicity island protein	-
MUA16_RS04365 (891167)	891167..891376	+	210	WP_045178617.1	hypothetical protein	Antitoxin
MUA16_RS04370 (891379)	891379..891705	+	327	WP_045178618.1	DUF1474 family protein	Toxin
MUA16_RS04375 (891770)	891770..892639	+	870	WP_262519388.1	primase alpha helix C-terminal domain-containing protein	-
MUA16_RS04380 (892656)	892656..894125	+	1470	WP_250414443.1	virulence-associated E family protein	-
MUA16_RS04385 (894405)	894405..894767	+	363	WP_045178622.1	hypothetical protein	-
MUA16_RS04390 (894769)	894769..895032	+	264	WP_001804819.1	hypothetical protein	-
MUA16_RS04395 (895034)	895034..895675	+	642	WP_252580283.1	pathogenicity island protein	-
MUA16_RS04400 (896022)	896022..896363	+	342	WP_262516299.1	pathogenicity island protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	887030..901532	14502

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-100)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 109 a.a.
• Molecular weight: 13165.42 Da
• Isoelectric Point: 4.5527

>T240488 WP_045178618.1 NZ_CP094797:891379-891705 [Staphylococcus aureus]
MNWEINDLFSDLKVLKDRFEDLKDNHGWHFEELYPHEPNHNLNKDELIREGFSYHERRIHNNQMFDLFHLYIEQFDNIIE
KFHEIEKASSENFGEESDDAKNSIKVAE

Nucleotide

• Length: 327 bp

>T240488 NZ_LT556084:1468285-1468692 [Citrobacter amalonaticus]
GTGGTCCTGTGGCAATCTGATCTCCGCGTCTCATGGCGCGCACAGTGGCTATCACTCCTTCTGCATGGGCTGGTGGCCGC
GGCGATTCTATTAATGCCATGGCCGCTGAGCTACACGCCGCTGTGGTTGATACTGCTTTCGCTGGTGGTGTTTGACTGTG
TCCGCAGCCAGCGGCGAATTAACGCCCGTCAGGGAGAGGTCAAACTTCTGATGGATGGACGGCTCCGCTGGCAGGGGCAG
GACTGGCTTATCGTCAGTGCACCGTGGATGATCAAAACCGGCATGATGCTGCGCTTGCGCTCAGAAACCGGTAAACGCCA
GCATTTGTGGCTCGCGGCTGACAGTATGGATAAGGCGGAATGGCGGGATTTACGCCGCCTGATGATGCAACCGTCGACGC
AAGGGTAG

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8237.34 Da
• Isoelectric Point: 4.6311

>AT240488 WP_045178617.1 NZ_CP094797:891167-891376 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLKLSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT240488 NZ_LT556084:1468038-1468304 [Citrobacter amalonaticus]
ATGGATATTAACAATAAAGCACGTATTCACTGGGCATGCCGACGCGGTATGCGTGAACTCGATATTTCCATCATGCCGTT
TTTCGAACATGAATACGACACGTTGAGTGATGATGAAAAACGTATTTTTATCCGCCTGTTGGAGTGTGATGACCCGGATT
TATTCAACTGGTTGATGAATCACGGTAAACCGGCAGATGCTGAACTGGAGCAGATGGTACGACTCATCCAGACACGGAAT
CGGGATCGTGGTCCTGTGGCAATCTGA