Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 874549..875026 Replicon chromosome
Accession NZ_CP094797
Organism Staphylococcus aureus strain IVB6163

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag MUA16_RS04235 Protein ID WP_000052076.1
Coordinates 874549..874737 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag MUA16_RS04240 Protein ID WP_001059690.1
Coordinates 874766..875026 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA16_RS04205 (870502) 870502..871059 + 558 WP_000824491.1 hypothetical protein -
MUA16_RS04210 (871400) 871400..872086 + 687 WP_001574556.1 thermonuclease family protein -
MUA16_RS04215 (872443) 872443..872643 + 201 WP_001059082.1 cold-shock protein -
MUA16_RS04220 (873140) 873140..873358 - 219 WP_000005879.1 hypothetical protein -
MUA16_RS04225 (873420) 873420..873704 - 285 WP_001004401.1 hypothetical protein -
MUA16_RS04230 (873792) 873792..874361 - 570 WP_001106663.1 lipoprotein N-acylation protein LnsA -
MUA16_RS04235 (874549) 874549..874737 - 189 WP_000052076.1 hypothetical protein Toxin
MUA16_RS04240 (874766) 874766..875026 - 261 WP_001059690.1 hypothetical protein Antitoxin
MUA16_RS04245 (875367) 875367..875570 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
MUA16_RS04250 (875567) 875567..875803 - 237 WP_000368687.1 hypothetical protein -
MUA16_RS04255 (876028) 876028..876609 + 582 WP_001140696.1 histidine phosphatase family protein -
MUA16_RS04260 (876682) 876682..877299 - 618 WP_000255548.1 LysE/ArgO family amino acid transporter -
MUA16_RS04265 (877455) 877455..877949 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
MUA16_RS04270 (878348) 878348..878770 - 423 WP_000974455.1 organic hydroperoxide resistance protein -
MUA16_RS04275 (878918) 878918..879634 + 717 WP_000150025.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T240487 WP_000052076.1 NZ_CP094797:c874737-874549 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T240487 NZ_LT556084:1351488-1351829 [Citrobacter amalonaticus]
ATGAAAATTCTACCTGCTACAATTTCGCGGGCGGCGAAGCCCTGCCTGCCGCCCGTTGCAGTCTGGCAAATGCTTCTTAC
ACGGCTACTGGAAAAACACTATGGCCTGACCCTGAACGATACGCCGTTCAGTGATGAAATCGTTATAAAGGAACATATCG
ATGCCGGTATCACGCTGGCCGATGCCGTTAACTTTCTGGTGGAAAAATACGAGCTGGTTCGAATAGATCGCAAAGGATTT
AGTTGGCAGGAACAATCCCCGTATCTTCGGGCTGTAGATATTCTGCGGGCAAGACAGGCAACTGGCCTGTTGCGACAAAG
CCGTAACAACGCAGTACGGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT240487 WP_001059690.1 NZ_CP094797:c875026-874766 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT240487 NZ_LT556084:1351150-1351467 [Citrobacter amalonaticus]
ATGAGCAACATCACATGGGGCCTGCAGCGGGATATCACGCCACGCCTGGGAGCCCGTCTGGTGCAGGAGGGGAACCGGCT
GCATTATCTGGCTGACCGGGCCAGTATCACCGGTAAATTCAGTGATGCCGAATGTCTTAAGCTGGATGTGGCATTCCCGC
ACTTTATCAGCCAGATCGAGTCGATGCTGACCACCTATGAACTGAATCCCCGACACGCCCACTGCGTCACCCTGTGCCAC
AACGGTTTTACCTGCGAAGCCGATACCCTTGGCAGTTGCGGCTATGTATACGTCGCTGTTTATTCCACTCAACGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References