Detailed information of TA system TA240486

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 434321..434859
• Replicon: chromosome
• Accession: NZ_CP094797
• Organism: Staphylococcus aureus strain IVB6163

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: -
• Locus tag: MUA16_RS02060
• Protein ID: WP_045178618.1
• Coordinates: 434533..434859 (+)
• Length: 109 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: -
• Locus tag: MUA16_RS02055
• Protein ID: WP_045178617.1
• Coordinates: 434321..434530 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA16_RS02025 (429845)	429845..431386	+	1542	WP_000424963.1	glutamine-hydrolyzing GMP synthase	-
MUA16_RS02030 (431480)	431480..432616	-	1137	WP_045178614.1	site-specific integrase	-
MUA16_RS02035 (432700)	432700..433485	-	786	WP_262519387.1	helix-turn-helix transcriptional regulator	-
MUA16_RS02040 (433602)	433602..433829	+	228	WP_000494396.1	helix-turn-helix transcriptional regulator	-
MUA16_RS02045 (433875)	433875..434135	+	261	WP_000080597.1	hypothetical protein	-
MUA16_RS02050 (434182)	434182..434328	+	147	WP_172643983.1	hypothetical protein	-
MUA16_RS02055 (434321)	434321..434530	+	210	WP_045178617.1	hypothetical protein	Antitoxin
MUA16_RS02060 (434533)	434533..434859	+	327	WP_045178618.1	DUF1474 family protein	Toxin
MUA16_RS02065 (434924)	434924..435793	+	870	WP_262519388.1	primase alpha helix C-terminal domain-containing protein	-
MUA16_RS02070 (435810)	435810..437267	+	1458	WP_262519389.1	virulence-associated E family protein	-
MUA16_RS02075 (437568)	437568..437930	+	363	WP_045178622.1	hypothetical protein	-
MUA16_RS02080 (437932)	437932..438216	+	285	WP_045178623.1	hypothetical protein	-
MUA16_RS02085 (438213)	438213..438854	+	642	WP_262519390.1	pathogenicity island protein	-
MUA16_RS02090 (439202)	439202..439543	+	342	WP_001190600.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	427048..447508	20460

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-100)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 109 a.a.
• Molecular weight: 13165.42 Da
• Isoelectric Point: 4.5527

>T240486 WP_045178618.1 NZ_CP094797:434533-434859 [Staphylococcus aureus]
MNWEINDLFSDLKVLKDRFEDLKDNHGWHFEELYPHEPNHNLNKDELIREGFSYHERRIHNNQMFDLFHLYIEQFDNIIE
KFHEIEKASSENFGEESDDAKNSIKVAE

Nucleotide

• Length: 327 bp

>T240486 NZ_LT556084:1147531-1148007 [Citrobacter amalonaticus]
ATGGATTTTCCCACATGGCTGAACGGGTGGACGATCTACGCTCATCCCTGTTTTATCGATCAATACAACGCGCTGGTCGC
ACGTGTTGAAGACCTTAAGCACAGGTTTCCAGATCCCATTGTTTTCCAGAAGAAGAAAGAGACCATGGTGCTGGCGCATT
TATTGAAATCCATTGCCAACATTACCCACGAACCCCGAGCTTCTGTTTACCGGCCTGGTGACAGTATAGGGAAAGCTTAT
ACAGACTGGTCGAGAGCGAAGTTTGGTGGGGGACGGTATCGCTTATTTTTCCGTTATAGTCTCGAGAGTAAGATCATTGT
CATCGCATGGGTGAATGATGAAGGGTCATTGCGCACCTGCGGCAGCAAGACCGATGCCTATAAGATTTTCGGGAAAATGC
TTGATGAGGGGAATCCACCCGACGACTGGCTAAGTTTGCTTCAGGCTTGTCAAAACGACGGGAAGGAACATCTTTGA

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8237.34 Da
• Isoelectric Point: 4.6311

>AT240486 WP_045178617.1 NZ_CP094797:434321-434530 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLKLSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT240486 NZ_LT556084:1147191-1147526 [Citrobacter amalonaticus]
ATGTTCGCCTATGTTCGATCTGAAGACATTGCCATTGAAGCGGATTCTAAATTGACGGAACGACATCAAACGACTATCCC
TGCGTCGATCAGGGACGCTTTACATCTTCGCAGTGGTGATCGTATTCATTACACATTGCTTTCCACGGGTGAAGTACTGC
TTTCAAAATACAGTGAAGCAACGGAGGACGGTGTGATGCGATCATTCCTGGACTTCTTATCACAGGATGTGGCGAATAAC
CCACAAACGCTGAAGAAGCTGGATTTATCCCGTGGCTATGAACTGGTTGATGGTATCGACGTCAATCTTGATGATGAAAT
CAGCGACGAAGACTGA