Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2188181..2188767 Replicon chromosome
Accession NC_012943
Organism Mycobacterium tuberculosis KZN 1435

Toxin (Protein)


Gene name mazF Uniprot ID G0TLY3
Locus tag TBMG_RS10440 Protein ID WP_003410010.1
Coordinates 2188423..2188767 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID P0CL58
Locus tag TBMG_RS10435 Protein ID WP_003410014.1
Coordinates 2188181..2188429 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TBMG_RS10415 2184164..2184931 - 768 WP_003410019.1 hemerythrin domain-containing protein -
TBMG_RS10420 2185088..2185444 + 357 WP_003410018.1 Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR -
TBMG_RS10425 2185497..2185769 + 273 WP_003410017.1 DUF1490 family protein -
TBMG_RS10430 2185766..2188081 + 2316 WP_003899120.1 cation transporter ATPase CptG -
TBMG_RS10435 2188181..2188429 + 249 WP_003410014.1 ribbon-helix-helix protein, CopG family Antitoxin
TBMG_RS10440 2188423..2188767 + 345 WP_003410010.1 type II toxin-antitoxin system toxin endoribonuclease MazF6 Toxin
TBMG_RS10445 2188856..2189191 + 336 WP_003410009.1 dehydrogenase -
TBMG_RS10450 2189092..2189349 - 258 WP_003410006.1 hypothetical protein -
TBMG_RS10455 2189435..2189776 + 342 WP_003410003.1 DUF2384 domain-containing protein -
TBMG_RS10460 2189773..2190333 + 561 WP_003410001.1 RES family NAD+ phosphorylase -
TBMG_RS10465 2190853..2191392 - 540 WP_003900446.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37) -
TBMG_RS10470 2191618..2192046 - 429 WP_003906713.1 cellulose-binding protein -
TBMG_RS10475 2192462..2193061 - 600 WP_003409989.1 L-lysine exporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-112)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-38)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 12230.12 Da        Isoelectric Point: 9.8887

>T24048 WP_003410010.1 NC_012943:2188423-2188767 [Mycobacterium tuberculosis KZN 1435]
VVISRAEIYWADLGPPSGSQPAKRRPVLVIQSDPYNASRLATVIAAVITSNTALAAMPGNVFLPATTTRLPRDSVVNVTA
IVTLNKTDLTDRVGEVPASLMHEVDRGLRRVLDL

Download         Length: 345 bp

>T24048 NC_012943:2188423-2188767 [Mycobacterium tuberculosis KZN 1435]
GTGGTGATTAGTCGTGCCGAGATCTACTGGGCTGACCTCGGGCCGCCATCAGGCAGTCAGCCGGCGAAGCGCCGCCCGGT
GCTCGTAATCCAGTCAGATCCGTACAACGCAAGTCGCCTTGCCACTGTGATCGCAGCGGTGATCACGTCCAATACGGCGC
TGGCGGCAATGCCCGGCAACGTGTTCTTGCCCGCGACCACAACGCGACTGCCACGTGACTCGGTCGTCAACGTCACGGCG
ATTGTCACGCTCAACAAGACTGACCTCACCGACCGAGTTGGGGAGGTGCCAGCGAGCTTGATGCACGAGGTTGACCGAGG
ACTTCGTCGCGTACTGGACCTTTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9290.34 Da        Isoelectric Point: 4.3757

>AT24048 WP_003410014.1 NC_012943:2188181-2188429 [Mycobacterium tuberculosis KZN 1435]
MKTAISLPDETFDRVSRRASELGMSRSEFFTKAAQRYLHELDAQLLTGQIDRALESIHGTDEAEALAVANAYRVLETMDD
EW

Download         Length: 249 bp

>AT24048 NC_012943:2188181-2188429 [Mycobacterium tuberculosis KZN 1435]
ATGAAGACAGCTATTTCTCTGCCGGATGAGACGTTCGATCGGGTATCGCGGCGTGCGAGTGAGCTCGGCATGAGTCGGTC
CGAGTTCTTCACGAAGGCTGCGCAGCGCTACCTGCACGAGCTGGACGCCCAATTGCTCACGGGCCAGATCGACAGGGCTC
TAGAGAGCATCCATGGCACCGACGAAGCGGAGGCCCTCGCCGTGGCCAACGCATACCGCGTGCTAGAAACCATGGACGAT
GAGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5HK3
PDB 5HK0
PDB 5HKC

Antitoxin

Source ID Structure
PDB 7WJ0
PDB 7WNR
AlphaFold DB A0A7U4FAW9

References