Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2098103..2098617 Replicon chromosome
Accession NZ_CP094795
Organism Staphylococcus aureus strain IVB6164

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag MUA75_RS10265 Protein ID WP_000581792.1
Coordinates 2098103..2098312 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag MUA75_RS10270 Protein ID WP_000138934.1
Coordinates 2098324..2098617 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA75_RS10245 (MUA75_10235) 2093611..2094969 - 1359 WP_262629747.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
MUA75_RS10250 (MUA75_10240) 2094984..2096054 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
MUA75_RS10255 (MUA75_10245) 2096372..2097574 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
MUA75_RS10260 (MUA75_10250) 2097838..2097975 - 138 WP_000828354.1 Lmo0850 family protein -
MUA75_RS10265 (MUA75_10255) 2098103..2098312 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
MUA75_RS10270 (MUA75_10260) 2098324..2098617 - 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
MUA75_RS10275 (MUA75_10265) 2098783..2100267 + 1485 WP_000571557.1 cardiolipin synthase -
MUA75_RS10280 (MUA75_10270) 2100295..2100942 + 648 WP_001187631.1 HD domain-containing protein -
MUA75_RS10285 (MUA75_10275) 2101608..2102480 - 873 WP_000725802.1 membrane protein insertase YidC -
MUA75_RS10290 (MUA75_10280) 2102566..2103207 - 642 WP_000483148.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T240478 WP_000581792.1 NZ_CP094795:c2098312-2098103 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T240478 NZ_LT549890:1157342-1157734 [Saccharolobus solfataricus]
ATGAAAGATAAGGAATTCTTGCTCGATGCCTCAGCTTTGTATTCACTTTTAGATTACGTGGATAAGGTAGATGTTAAGAA
AATTCATGTACTTACCCTAACTTTTTATGAGGTAGGTAATGTCATATGGAAGGAGTATTATATACATAAAAAGGTTAAAG
ATCCTATAACCCTTTCGAGGCTTTTCTATAAATTAATGCGAAAATTTAACGTAATAGAGGATTCGCCTCTTGAGGGGGTA
ATGAGAATTGCCATAGAAAGGGGTTTAACTTACTATAACGCATCTTATGCGTATGTTGCTGAATCTTTAGGGCTTATCCT
AGTGTCTAACGATAAAGAGTTGATAAGAAAGGCTAACGCTATTTCGTTAAAGGATTTGATAAAAAGTATGTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT240478 WP_000138934.1 NZ_CP094795:c2098617-2098324 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT240478 NZ_LT549890:1157128-1157352 [Saccharolobus solfataricus]
ATGTCAGACGTAATAAGCGTAAGAGTGAAGAAAGAGCTAAAGAAGAAGGCAGAGGAGTTAGGAATTAACGTTAGGGAAGT
TGTAGAAAAAGCTTTAGAGGAAGCCATAAGGGAGAAGGAGAAGGAAGAGCTTAAGGATATGACTATGAAAATTAAGGAAC
TAATGAGGGACGTAAGTGAATATGATTGGGTAAGTACTGTTAGGGAGAGTAGGGATGAAAGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References