Detailed information of TA system TA240477

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 2078358..2078887
• Replicon: chromosome
• Accession: NZ_CP094795
• Organism: Staphylococcus aureus strain IVB6164

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: MUA75_RS10175
• Protein ID: WP_000621175.1
• Coordinates: 2078358..2078720 (-)
• Length: 121 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: T1YCG8
• Locus tag: MUA75_RS10180
• Protein ID: WP_000948331.1
• Coordinates: 2078717..2078887 (-)
• Length: 57 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA75_RS10155 (MUA75_10145)	2075336..2076106	-	771	WP_001041107.1	RNA polymerase sigma factor SigB	-
MUA75_RS10160 (MUA75_10150)	2076081..2076560	-	480	WP_001190825.1	anti-sigma B factor RsbW	-
MUA75_RS10165 (MUA75_10155)	2076562..2076888	-	327	WP_001052491.1	anti-sigma factor antagonist	-
MUA75_RS10170 (MUA75_10160)	2077007..2078008	-	1002	WP_000390829.1	PP2C family protein-serine/threonine phosphatase	-
MUA75_RS10175 (MUA75_10165)	2078358..2078720	-	363	WP_000621175.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
MUA75_RS10180 (MUA75_10170)	2078717..2078887	-	171	WP_000948331.1	type II toxin-antitoxin system antitoxin MazE	Antitoxin
MUA75_RS10185 (MUA75_10175)	2078972..2080120	-	1149	WP_001281160.1	alanine racemase	-
MUA75_RS10190 (MUA75_10180)	2080186..2080545	-	360	WP_000581198.1	holo-ACP synthase	-
MUA75_RS10195 (MUA75_10185)	2080549..2081040	-	492	WP_001205919.1	PH domain-containing protein	-
MUA75_RS10200 (MUA75_10190)	2081027..2082610	-	1584	WP_262629740.1	PH domain-containing protein	-
MUA75_RS10205 (MUA75_10195)	2082603..2083082	-	480	WP_001287083.1	hypothetical protein	-
MUA75_RS10210 (MUA75_10200)	2083291..2083851	-	561	WP_001092403.1	K(+)-transporting ATPase subunit C	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-110)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 121 a.a.
• Molecular weight: 13441.69 Da
• Isoelectric Point: 10.1654

>T240477 WP_000621175.1 NZ_CP094795:c2078720-2078358 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Nucleotide

• Length: 363 bp

>T240477 NZ_LT222319:c4177715-4177533 [Pseudomonas cerasi]
GTGCAGAGCAGGCAATTGATAAAGGAGCTTGAAGCAGATGGATGGATTCTGGATCGTGTTTCAGGCAGTCACCATATGTT
CAAGCATCCTGAAAAACTTCAGACAGTCCCCGTACCGCATCCCAAGAAAGACTTGCCATTCGGAACGGTGCGGGCCATCA
AAAAGCTTGCCGGGCTGGTTTAG

Antitoxin

Protein

• Length: 57 a.a.
• Molecular weight: 6251.78 Da
• Isoelectric Point: 3.8305

>AT240477 WP_000948331.1 NZ_CP094795:c2078887-2078717 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Nucleotide

• Length: 171 bp

>AT240477 NZ_LT222319:c4177497-4177093 [Pseudomonas cerasi]
ATGAAATATCCAATGTGCATAGAATGGGGAAGCGAAACCACGGCGTTTGGTATCCAGATTCCCGATATCCCAGGTGCCGT
AACCGCAGGCGATACGTTCGAGGAAGCCCACGCCGCGGCGGTGGAGATTGCTCATATCATGCTTCAGGAAATAGCAGCTG
GTGGTGGAACCATACCCAAGGCCGGCACTGTTGCCGAGCACGCCAGGAATGCCGATTTCGCCGGAATGGGCTGGGGCATG
ATCGAGATTGACGTAACGCCTTATCTTGGTAAGACGGAGAAGGTCAACGTCACACTGCCTGGTTTCGTGATCAAGCAGAT
CGATCGCTATGTACGGGATCACAGCATCAAGAGTCGTTCCACCTTCCTGGCCGACGCGGCGCTGGAAAAACTGGGCCGGG
CATGA

Structures

Antitoxin

• AlphaFold DB: A0A0E0VRZ1