Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1920278..1921054 Replicon chromosome
Accession NZ_CP094795
Organism Staphylococcus aureus strain IVB6164

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag MUA75_RS09265 Protein ID WP_000031108.1
Coordinates 1920278..1920430 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID A0A0D1IYN8
Locus tag MUA75_RS09270 Protein ID WP_001251219.1
Coordinates 1920455..1921054 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA75_RS09250 (MUA75_09240) 1916282..1917103 + 822 WP_262629728.1 RluA family pseudouridine synthase -
MUA75_RS09255 (MUA75_09245) 1917553..1918938 - 1386 WP_000116236.1 class II fumarate hydratase -
MUA75_RS09260 (MUA75_09250) 1919134..1919529 - 396 WP_000901023.1 hypothetical protein -
MUA75_RS09265 (MUA75_09255) 1920278..1920430 - 153 WP_000031108.1 SAS053 family protein Toxin
MUA75_RS09270 (MUA75_09260) 1920455..1921054 - 600 WP_001251219.1 glucosamine-6-phosphate isomerase Antitoxin
MUA75_RS09275 (MUA75_09265) 1921213..1921683 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
MUA75_RS09280 (MUA75_09270) 1921688..1922815 - 1128 WP_000379981.1 tRNA epoxyqueuosine(34) reductase QueG -
MUA75_RS09285 (MUA75_09275) 1922966..1923688 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
MUA75_RS09290 (MUA75_09280) 1923681..1925138 - 1458 WP_000649902.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T240476 WP_000031108.1 NZ_CP094795:c1920430-1920278 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

>T240476 NZ_LT222319:c913434-913030 [Pseudomonas cerasi]
ATGCTCAAGTACATGCTTGACACCAATATTTGCATTTTCACTATAAAGAACAAGCCAACTTCGGTGCGTGAAGCCTTCAA
CCTCCATCATGGACAGCTATGTATCAGCGCGATCACGTTGATGGAGCTTGTCTACGGCGCAGAAAAGTCTTTGAGCCCCG
AAAGAAACCTTGCCGTTGTAGAGGGTTTCACAGCGCGTCTTGAAGTGCTCCCTTACGACAGCGACGCTGCGGCTCATACC
GGCATGATCAGAGCCGAACTGGCTAGATCGGGCACACCGATCGGCCCGTACGATCAAATGATTGCAGGACACGCCCGCTC
TCTAGGCCTGGTGGTGATCACTAATAATCAGCGTGAATTCCGACGCGTCGAGGGGCTGAGGGTAGAAGACTGGGTAAGCC
AATGA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22357.50 Da        Isoelectric Point: 5.1445

>AT240476 WP_001251219.1 NZ_CP094795:c1921054-1920455 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNIEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp

>AT240476 NZ_LT222319:c913664-913434 [Pseudomonas cerasi]
ATGGAACAATCCACAGTCTTCAAAAGCAATCGAAGCCAGGCTGTCCGACTGCCAAAAGCGGTCGCCTTGCCAAACGACGT
GAAACGTGTCGATGTCGTAGCCGTGGGCAGAACCCGCATTATTTCCCCCGCTGGTGAAATGTGGAACAGCTGGTTCGATG
GTGAAAGTGTCAGTGATGATTTCATGGCAGAGCGTGAACAACCAGCCGAACAGCAGCGCGAATCGCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1IYN8

References