Detailed information of TA system TA240475

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 879483..879960
• Replicon: chromosome
• Accession: NZ_CP094795
• Organism: Staphylococcus aureus strain IVB6164

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: T1Y7S2
• Locus tag: MUA75_RS04270
• Protein ID: WP_000052076.1
• Coordinates: 879483..879671 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: T1Y6P8
• Locus tag: MUA75_RS04275
• Protein ID: WP_001059690.1
• Coordinates: 879700..879960 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA75_RS04240 (MUA75_04230)	875472..875993	+	522	WP_262630094.1	hypothetical protein	-
MUA75_RS04245 (MUA75_04235)	876334..877020	+	687	WP_000141556.1	thermonuclease family protein	-
MUA75_RS04250 (MUA75_04240)	877377..877577	+	201	WP_001059082.1	cold-shock protein	-
MUA75_RS04255 (MUA75_04245)	878074..878292	-	219	WP_000005883.1	hypothetical protein	-
MUA75_RS04260 (MUA75_04250)	878354..878638	-	285	WP_001004401.1	hypothetical protein	-
MUA75_RS04265 (MUA75_04255)	878726..879295	-	570	WP_001106648.1	lipoprotein N-acylation protein LnsA	-
MUA75_RS04270 (MUA75_04260)	879483..879671	-	189	WP_000052076.1	hypothetical protein	Toxin
MUA75_RS04275 (MUA75_04265)	879700..879960	-	261	WP_001059690.1	hypothetical protein	Antitoxin
MUA75_RS04280 (MUA75_04270)	880301..880504	+	204	WP_000145163.1	sterile alpha motif-like domain-containing protein	-
MUA75_RS04285 (MUA75_04275)	880501..880737	-	237	WP_000368687.1	hypothetical protein	-
MUA75_RS04290 (MUA75_04280)	880962..881543	+	582	WP_001140696.1	histidine phosphatase family protein	-
MUA75_RS04295 (MUA75_04285)	881616..882233	-	618	WP_000255565.1	LysE/ArgO family amino acid transporter	-
MUA75_RS04300 (MUA75_04290)	882389..882883	-	495	WP_000569881.1	GNAT family N-acetyltransferase	-
MUA75_RS04305 (MUA75_04295)	883282..883704	-	423	WP_000974462.1	organic hydroperoxide resistance protein	-
MUA75_RS04310 (MUA75_04300)	883852..884568	+	717	WP_000150032.1	type I 3-dehydroquinate dehydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-90)

Antitoxin

• Ribbon-helix-helix protein, CopG (10-47)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7142.82 Da
• Isoelectric Point: 9.9971

>T240475 WP_000052076.1 NZ_CP094795:c879671-879483 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T240475 NZ_LT222318:c8594-8319 [Pseudomonas cerasi]
ATGGAATTGAAGTGGACAAGCAAGGCGCTTTCCGACATTACCAGGCTATACGAGTTTCTGGCCTTGGCGAATCAACCTGC
CGCAGCACGAGTAGTGCAGCAACTCACCACAGCACCTACCACGCTTCTGACTAACCCGCGCATTGGCGAACGCCTAGAGG
AGTTCGAGCCAAAGGACGTACGCCGAATTCAGATCGGCCAATACGAGATGCGTTACGAGGTAGCGGATTCAACTATTTAC
CTGCTGCGCCTGTGGCACACCCGCGAAGACCGATAG

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9940.09 Da
• Isoelectric Point: 4.0624

>AT240475 WP_001059690.1 NZ_CP094795:c879960-879700 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Nucleotide

• Length: 261 bp

>AT240475 NZ_LT222318:c8866-8594 [Pseudomonas cerasi]
ATGGCAACCACCGCCAAAACCCGATCTGTCACAGCTCACGTTCCGGTTCAGCTGGCGGAAAAAGTCGATTTGATGGCTGA
GCGTCTGGAGCGCTCTAAAAACTGGATCGTCAAGCAAGCCCTGTCTGCTTGGATAGACCAGGAAGAAGAGCGTAGTCGCC
TGACCCGTGAGGCCTTGGCTGATGTTGACGCTGGACGCGTTATTGATCACCAAGCCGTCCAGGCCTGGGCTGACAGTCTT
AGCACCGACACTCCGTTGCCGGTGCCGCGCTGA

Structures

Toxin

• AlphaFold DB: A0A0E0VP18

Antitoxin

• AlphaFold DB: A0A0E0VN56