Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1959434..1960210 Replicon chromosome
Accession NZ_CP094793
Organism Staphylococcus aureus strain IVB6165

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag MUA93_RS09500 Protein ID WP_000031108.1
Coordinates 1959434..1959586 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID A0A0D1IYN8
Locus tag MUA93_RS09505 Protein ID WP_001251219.1
Coordinates 1959611..1960210 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA93_RS09480 (MUA93_09470) 1955438..1956259 + 822 WP_000669377.1 RluA family pseudouridine synthase -
MUA93_RS09485 (MUA93_09475) 1956709..1958094 - 1386 WP_000116236.1 class II fumarate hydratase -
MUA93_RS09490 (MUA93_09480) 1958290..1958685 - 396 WP_000901023.1 hypothetical protein -
MUA93_RS09495 (MUA93_09485) 1958906..1959043 + 138 WP_162634120.1 hypothetical protein -
MUA93_RS09500 (MUA93_09490) 1959434..1959586 - 153 WP_000031108.1 SAS053 family protein Toxin
MUA93_RS09505 (MUA93_09495) 1959611..1960210 - 600 WP_001251219.1 glucosamine-6-phosphate isomerase Antitoxin
MUA93_RS09510 (MUA93_09500) 1960369..1960839 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
MUA93_RS09515 (MUA93_09505) 1960844..1961971 - 1128 WP_000379981.1 tRNA epoxyqueuosine(34) reductase QueG -
MUA93_RS09520 (MUA93_09510) 1962122..1962844 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
MUA93_RS09525 (MUA93_09515) 1962837..1964294 - 1458 WP_262541880.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T240467 WP_000031108.1 NZ_CP094793:c1959586-1959434 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

>T240467 NZ_LT220504:c2469497-2469237 [Lacticaseibacillus rhamnosus]
ATGATTAAAACCTGGACCGATGATGCTTGGGCGGACTACATGTATTGGCATGATCAAAACGACAAGCGGACAATCAAACG
AATTAATCAACTCATTCAAGCCATTGACCGTGACCCTTATAAAGGCATCGGAAAACCTGAGCCACTTAGATATGCGCTAA
CCGGAAAATGGTCACGTCGGATTGATCAGGAAAATCGCATCATCTACAGCATTGAAAAGAACCACATTAATATTTTCGCC
TGCCGCACTCACTACAGTTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22357.50 Da        Isoelectric Point: 5.1445

>AT240467 WP_001251219.1 NZ_CP094793:c1960210-1959611 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNIEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp

>AT240467 NZ_LT220504:c2469759-2469490 [Lacticaseibacillus rhamnosus]
ATGGAAGCAACGAATTATAGTGATTTCCGCCGCAACCTTAAGCATTATATGAGTCAAGTCAACGAAGACGCCGAACCGCT
ACTGGTTACCGCTAAAGATGATGATGACAATGTGGTGGTTATGAGCAAGCACGATTTTGACGCCATCGAAGAAACCCTGT
ATTTACTCAGCAATCCCAAGCTGATGGCCAAAATCAAACGTGGTGATGCCCAAATTGCCGCTGGAAAGGCTAAACAGCAC
GAGTTGTTAACGGACTTCGATCATGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1IYN8

References