Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_XRE(antitoxin)
Location 1582696..1583493 Replicon chromosome
Accession NZ_CP094793
Organism Staphylococcus aureus strain IVB6165

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag MUA93_RS07625 Protein ID WP_262541840.1
Coordinates 1583032..1583493 (+) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag MUA93_RS07620 Protein ID WP_001260486.1
Coordinates 1582696..1583019 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA93_RS07570 (MUA93_07560) 1578431..1578988 - 558 WP_000645049.1 DUF2815 family protein -
MUA93_RS07575 (MUA93_07565) 1579015..1580181 - 1167 WP_233665663.1 DUF2800 domain-containing protein -
MUA93_RS07580 (MUA93_07570) 1580178..1580540 - 363 WP_000985986.1 hypothetical protein -
MUA93_RS07585 (MUA93_07575) 1580555..1580878 - 324 WP_000175000.1 hypothetical protein -
MUA93_RS07590 (MUA93_07580) 1580957..1581118 - 162 WP_001285954.1 DUF1270 domain-containing protein -
MUA93_RS07595 (MUA93_07585) 1581131..1581394 - 264 WP_001124160.1 helix-turn-helix domain-containing protein -
MUA93_RS07600 (MUA93_07590) 1581419..1581634 - 216 WP_001097552.1 hypothetical protein -
MUA93_RS07605 (MUA93_07595) 1581689..1582054 + 366 WP_001128433.1 hypothetical protein -
MUA93_RS07610 (MUA93_07600) 1582023..1582268 - 246 WP_001025401.1 DUF2829 domain-containing protein -
MUA93_RS07615 (MUA93_07605) 1582284..1582532 - 249 WP_000272861.1 helix-turn-helix domain-containing protein -
MUA93_RS07620 (MUA93_07610) 1582696..1583019 + 324 WP_001260486.1 helix-turn-helix transcriptional regulator Antitoxin
MUA93_RS07625 (MUA93_07615) 1583032..1583493 + 462 WP_262541840.1 toxin Toxin
MUA93_RS07630 (MUA93_07620) 1583511..1583945 + 435 WP_031903825.1 hypothetical protein -
MUA93_RS07635 (MUA93_07625) 1583973..1584368 + 396 WP_001558060.1 hypothetical protein -
MUA93_RS07640 (MUA93_07630) 1584476..1584667 + 192 WP_252559444.1 hypothetical protein -
MUA93_RS07645 (MUA93_07635) 1584664..1584951 - 288 WP_258415362.1 hypothetical protein -
MUA93_RS07650 (MUA93_07640) 1585368..1586573 + 1206 WP_000264747.1 site-specific integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1538900..1604204 65304


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(8-65)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 18062.40 Da        Isoelectric Point: 4.6915

>T240466 WP_262541840.1 NZ_CP094793:1583032-1583493 [Staphylococcus aureus]
MGLYEETLIQHDYIETREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Download         Length: 462 bp

>T240466 NZ_LT220504:1745310-1745495 [Lacticaseibacillus rhamnosus]
TTGCAGCGTCAAGGTCATGTAAAATTAGCTTCTCTACATGACCATGCTTTAAAGGGTGCTCACAGCGGCGAACGAGCATT
GCGTGTTGCTCCTGATTGGCTTCTCGTTTATAAAGTCGATGCTGAAGCGTTAATTTTAATGCTTCTTGCAACAGGCACAC
ACCGCGATACATTGAACATTGAGTAA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12427.10 Da        Isoelectric Point: 9.3811

>AT240466 WP_001260486.1 NZ_CP094793:1582696-1583019 [Staphylococcus aureus]
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQPENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK

Download         Length: 324 bp

>AT240466 NZ_LT220504:1745010-1745282 [Lacticaseibacillus rhamnosus]
ATGACCAAAAAATCCCGCATCAGCGTTAGGATTGATACCAAAACTAAAGAACGAGCGCTCCATGTTCTTAATAGCATGGG
ATTAGATATTTCCTCGGCTATTAACATGTACCTGAAACGGATTGGTGACACCGGTGCATTGCCATTTACACCTCCAATGT
CATTTGTTGATCAGCTTCAAGTTGCAGAAGCTGATGTTAAAGCGGGGCGAATAAAAAGCTTCAAGACTGTCGATGCTTTG
ATGAAGGATTTATACAGTGATGTTGACGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References