Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /HTH_XRE(antitoxin) |
| Location | 1582696..1583493 | Replicon | chromosome |
| Accession | NZ_CP094793 | ||
| Organism | Staphylococcus aureus strain IVB6165 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | - |
| Locus tag | MUA93_RS07625 | Protein ID | WP_262541840.1 |
| Coordinates | 1583032..1583493 (+) | Length | 154 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | - |
| Locus tag | MUA93_RS07620 | Protein ID | WP_001260486.1 |
| Coordinates | 1582696..1583019 (+) | Length | 108 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MUA93_RS07570 (MUA93_07560) | 1578431..1578988 | - | 558 | WP_000645049.1 | DUF2815 family protein | - |
| MUA93_RS07575 (MUA93_07565) | 1579015..1580181 | - | 1167 | WP_233665663.1 | DUF2800 domain-containing protein | - |
| MUA93_RS07580 (MUA93_07570) | 1580178..1580540 | - | 363 | WP_000985986.1 | hypothetical protein | - |
| MUA93_RS07585 (MUA93_07575) | 1580555..1580878 | - | 324 | WP_000175000.1 | hypothetical protein | - |
| MUA93_RS07590 (MUA93_07580) | 1580957..1581118 | - | 162 | WP_001285954.1 | DUF1270 domain-containing protein | - |
| MUA93_RS07595 (MUA93_07585) | 1581131..1581394 | - | 264 | WP_001124160.1 | helix-turn-helix domain-containing protein | - |
| MUA93_RS07600 (MUA93_07590) | 1581419..1581634 | - | 216 | WP_001097552.1 | hypothetical protein | - |
| MUA93_RS07605 (MUA93_07595) | 1581689..1582054 | + | 366 | WP_001128433.1 | hypothetical protein | - |
| MUA93_RS07610 (MUA93_07600) | 1582023..1582268 | - | 246 | WP_001025401.1 | DUF2829 domain-containing protein | - |
| MUA93_RS07615 (MUA93_07605) | 1582284..1582532 | - | 249 | WP_000272861.1 | helix-turn-helix domain-containing protein | - |
| MUA93_RS07620 (MUA93_07610) | 1582696..1583019 | + | 324 | WP_001260486.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| MUA93_RS07625 (MUA93_07615) | 1583032..1583493 | + | 462 | WP_262541840.1 | toxin | Toxin |
| MUA93_RS07630 (MUA93_07620) | 1583511..1583945 | + | 435 | WP_031903825.1 | hypothetical protein | - |
| MUA93_RS07635 (MUA93_07625) | 1583973..1584368 | + | 396 | WP_001558060.1 | hypothetical protein | - |
| MUA93_RS07640 (MUA93_07630) | 1584476..1584667 | + | 192 | WP_252559444.1 | hypothetical protein | - |
| MUA93_RS07645 (MUA93_07635) | 1584664..1584951 | - | 288 | WP_258415362.1 | hypothetical protein | - |
| MUA93_RS07650 (MUA93_07640) | 1585368..1586573 | + | 1206 | WP_000264747.1 | site-specific integrase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1538900..1604204 | 65304 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 154 a.a. Molecular weight: 18062.40 Da Isoelectric Point: 4.6915
>T240466 WP_262541840.1 NZ_CP094793:1583032-1583493 [Staphylococcus aureus]
MGLYEETLIQHDYIETREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI
MGLYEETLIQHDYIETREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI
Download Length: 462 bp
>T240466 NZ_LT220504:1745310-1745495 [Lacticaseibacillus rhamnosus]
TTGCAGCGTCAAGGTCATGTAAAATTAGCTTCTCTACATGACCATGCTTTAAAGGGTGCTCACAGCGGCGAACGAGCATT
GCGTGTTGCTCCTGATTGGCTTCTCGTTTATAAAGTCGATGCTGAAGCGTTAATTTTAATGCTTCTTGCAACAGGCACAC
ACCGCGATACATTGAACATTGAGTAA
TTGCAGCGTCAAGGTCATGTAAAATTAGCTTCTCTACATGACCATGCTTTAAAGGGTGCTCACAGCGGCGAACGAGCATT
GCGTGTTGCTCCTGATTGGCTTCTCGTTTATAAAGTCGATGCTGAAGCGTTAATTTTAATGCTTCTTGCAACAGGCACAC
ACCGCGATACATTGAACATTGAGTAA
Antitoxin
Download Length: 108 a.a. Molecular weight: 12427.10 Da Isoelectric Point: 9.3811
>AT240466 WP_001260486.1 NZ_CP094793:1582696-1583019 [Staphylococcus aureus]
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQPENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQPENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK
Download Length: 324 bp
>AT240466 NZ_LT220504:1745010-1745282 [Lacticaseibacillus rhamnosus]
ATGACCAAAAAATCCCGCATCAGCGTTAGGATTGATACCAAAACTAAAGAACGAGCGCTCCATGTTCTTAATAGCATGGG
ATTAGATATTTCCTCGGCTATTAACATGTACCTGAAACGGATTGGTGACACCGGTGCATTGCCATTTACACCTCCAATGT
CATTTGTTGATCAGCTTCAAGTTGCAGAAGCTGATGTTAAAGCGGGGCGAATAAAAAGCTTCAAGACTGTCGATGCTTTG
ATGAAGGATTTATACAGTGATGTTGACGATTAA
ATGACCAAAAAATCCCGCATCAGCGTTAGGATTGATACCAAAACTAAAGAACGAGCGCTCCATGTTCTTAATAGCATGGG
ATTAGATATTTCCTCGGCTATTAACATGTACCTGAAACGGATTGGTGACACCGGTGCATTGCCATTTACACCTCCAATGT
CATTTGTTGATCAGCTTCAAGTTGCAGAAGCTGATGTTAAAGCGGGGCGAATAAAAAGCTTCAAGACTGTCGATGCTTTG
ATGAAGGATTTATACAGTGATGTTGACGATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|