Detailed information of TA system TA240462

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 871230..871707
• Replicon: chromosome
• Accession: NZ_CP094793
• Organism: Staphylococcus aureus strain IVB6165

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: T1Y7S2
• Locus tag: MUA93_RS04175
• Protein ID: WP_000052076.1
• Coordinates: 871230..871418 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: T1Y6P8
• Locus tag: MUA93_RS04180
• Protein ID: WP_001059690.1
• Coordinates: 871447..871707 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA93_RS04145 (MUA93_04135)	867219..867740	+	522	WP_000824476.1	hypothetical protein	-
MUA93_RS04150 (MUA93_04140)	868081..868767	+	687	WP_262542240.1	thermonuclease family protein	-
MUA93_RS04155 (MUA93_04145)	869124..869324	+	201	WP_001059082.1	cold-shock protein	-
MUA93_RS04160 (MUA93_04150)	869821..870039	-	219	WP_000005883.1	hypothetical protein	-
MUA93_RS04165 (MUA93_04155)	870101..870385	-	285	WP_001004401.1	hypothetical protein	-
MUA93_RS04170 (MUA93_04160)	870473..871042	-	570	WP_001106648.1	lipoprotein N-acylation protein LnsA	-
MUA93_RS04175 (MUA93_04165)	871230..871418	-	189	WP_000052076.1	hypothetical protein	Toxin
MUA93_RS04180 (MUA93_04170)	871447..871707	-	261	WP_001059690.1	hypothetical protein	Antitoxin
MUA93_RS04185 (MUA93_04175)	872048..872251	+	204	WP_000145163.1	sterile alpha motif-like domain-containing protein	-
MUA93_RS04190 (MUA93_04180)	872248..872484	-	237	WP_000368687.1	hypothetical protein	-
MUA93_RS04195 (MUA93_04185)	872709..873290	+	582	WP_001140696.1	histidine phosphatase family protein	-
MUA93_RS04200 (MUA93_04190)	873363..873980	-	618	WP_000255565.1	LysE/ArgO family amino acid transporter	-
MUA93_RS04205 (MUA93_04195)	874136..874630	-	495	WP_000569881.1	GNAT family N-acetyltransferase	-
MUA93_RS04210 (MUA93_04200)	875029..875451	-	423	WP_000974462.1	organic hydroperoxide resistance protein	-
MUA93_RS04215 (MUA93_04205)	875599..876315	+	717	WP_262542244.1	type I 3-dehydroquinate dehydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	vWbp	854149..895889	41740

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (8-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7142.82 Da
• Isoelectric Point: 9.9971

>T240462 WP_000052076.1 NZ_CP094793:c871418-871230 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T240462 NZ_LT009690:c2489872-2489606 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACAATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9940.09 Da
• Isoelectric Point: 4.0624

>AT240462 WP_001059690.1 NZ_CP094793:c871707-871447 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Nucleotide

• Length: 261 bp

>AT240462 NZ_LT009690:c2490123-2489872 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Structures

Toxin

• AlphaFold DB: A0A0E0VP18

Antitoxin

• AlphaFold DB: A0A0E0VN56