Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2234794..2235323 Replicon chromosome
Accession NZ_CP094791
Organism Staphylococcus aureus strain IVB6166

Toxin (Protein)


Gene name mazF Uniprot ID Q6GF05
Locus tag MUA80_RS11320 Protein ID WP_000621176.1
Coordinates 2234794..2235156 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag MUA80_RS11325 Protein ID WP_000948331.1
Coordinates 2235153..2235323 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA80_RS11300 (MUA80_11275) 2231772..2232542 - 771 WP_001041107.1 RNA polymerase sigma factor SigB -
MUA80_RS11305 (MUA80_11280) 2232517..2232996 - 480 WP_001190825.1 anti-sigma B factor RsbW -
MUA80_RS11310 (MUA80_11285) 2232998..2233324 - 327 WP_001052491.1 anti-sigma factor antagonist -
MUA80_RS11315 (MUA80_11290) 2233443..2234444 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
MUA80_RS11320 (MUA80_11295) 2234794..2235156 - 363 WP_000621176.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MUA80_RS11325 (MUA80_11300) 2235153..2235323 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
MUA80_RS11330 (MUA80_11305) 2235408..2236556 - 1149 WP_001281140.1 alanine racemase -
MUA80_RS11335 (MUA80_11310) 2236622..2236981 - 360 WP_000581197.1 holo-ACP synthase -
MUA80_RS11340 (MUA80_11315) 2236985..2237476 - 492 WP_001286801.1 PH domain-containing protein -
MUA80_RS11345 (MUA80_11320) 2237469..2239046 - 1578 Protein_2196 PH domain-containing protein -
MUA80_RS11350 (MUA80_11325) 2239039..2239518 - 480 WP_001287082.1 hypothetical protein -
MUA80_RS11355 (MUA80_11330) 2239727..2240287 - 561 WP_001092414.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13469.74 Da        Isoelectric Point: 10.1654

>T240453 WP_000621176.1 NZ_CP094791:c2235156-2234794 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVVHQKN

Download         Length: 363 bp

>T240453 NZ_LT009690:833940-834257 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTAATGTGTGACATTGAAGTGATAAAACAAAAAATTAATGATGTAGCTACCAAACATGC
TTGGTTTGTTGAAGATAGATTTGTAAAAAATGAATTAGAAACAAAACGGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACATGTGTACTTAAAAGAATTCGGTGAACTTATACAAAAATTT
CATGAAATAGAAAAAGCATCATCTGAGAACTTTGGCGAGGTATCAGATGACGCACAAAAATTAAAAATCACAGAGTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT240453 WP_000948331.1 NZ_CP094791:c2235323-2235153 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp

>AT240453 NZ_LT009690:833728-833937 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACGTGGTTTATCAACTTGAGTTAAGTGTCATGAATAACTTGGAAAGTTA
TGAACACACAGAATATGTTAATAGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A168PYX0

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References