Detailed information of TA system TA240445

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 934388..934865
• Replicon: chromosome
• Accession: NZ_CP094791
• Organism: Staphylococcus aureus strain IVB6166

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: T1Y7S2
• Locus tag: MUA80_RS04625
• Protein ID: WP_000052076.1
• Coordinates: 934388..934576 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: T1Y6P8
• Locus tag: MUA80_RS04630
• Protein ID: WP_001059690.1
• Coordinates: 934605..934865 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA80_RS04595 (MUA80_04575)	930341..930898	+	558	WP_045178710.1	hypothetical protein	-
MUA80_RS04600 (MUA80_04580)	931239..931925	+	687	WP_001574556.1	thermonuclease family protein	-
MUA80_RS04605 (MUA80_04585)	932282..932482	+	201	WP_001059082.1	cold-shock protein	-
MUA80_RS04610 (MUA80_04590)	932979..933197	-	219	WP_000005879.1	hypothetical protein	-
MUA80_RS04615 (MUA80_04595)	933259..933543	-	285	WP_001004401.1	hypothetical protein	-
MUA80_RS04620 (MUA80_04600)	933631..934200	-	570	WP_001106663.1	lipoprotein N-acylation protein LnsA	-
MUA80_RS04625 (MUA80_04605)	934388..934576	-	189	WP_000052076.1	hypothetical protein	Toxin
MUA80_RS04630 (MUA80_04610)	934605..934865	-	261	WP_001059690.1	hypothetical protein	Antitoxin
MUA80_RS04635 (MUA80_04615)	935206..935409	+	204	WP_000145163.1	sterile alpha motif-like domain-containing protein	-
MUA80_RS04640 (MUA80_04620)	935406..935642	-	237	WP_000368687.1	hypothetical protein	-
MUA80_RS04645 (MUA80_04625)	935866..936447	+	582	WP_001140696.1	histidine phosphatase family protein	-
MUA80_RS04650 (MUA80_04630)	936520..937137	-	618	WP_000255548.1	LysE/ArgO family amino acid transporter	-
MUA80_RS04655 (MUA80_04635)	937293..937787	-	495	WP_000569884.1	GNAT family N-acetyltransferase	-
MUA80_RS04660 (MUA80_04640)	938186..938608	-	423	WP_000974455.1	organic hydroperoxide resistance protein	-
MUA80_RS04665 (MUA80_04645)	938756..939472	+	717	WP_000150025.1	type I 3-dehydroquinate dehydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	tsst-1 / vWbp	902228..940094	37866

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7142.82 Da
• Isoelectric Point: 9.9971

>T240445 WP_000052076.1 NZ_CP094791:c934576-934388 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T240445 NZ_LS999560:c4815161-4814850 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGAACGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTCTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9940.09 Da
• Isoelectric Point: 4.0624

>AT240445 WP_001059690.1 NZ_CP094791:c934865-934605 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Nucleotide

• Length: 261 bp

>AT240445 NZ_LS999560:c4814849-4814559 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
ACGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCCGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG

Structures

Toxin

• AlphaFold DB: A0A0E0VP18

Antitoxin

• AlphaFold DB: A0A0E0VN56