240444

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TscAT/-
Location 484855..485393 Replicon chromosome
Accession NZ_CP094791
Organism Staphylococcus aureus strain IVB6166

Toxin (Protein)


Gene name TscT Uniprot ID -
Locus tag MUA80_RS02360 Protein ID WP_045178618.1
Coordinates 485067..485393 (+) Length 109 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID -
Locus tag MUA80_RS02355 Protein ID WP_045178617.1
Coordinates 484855..485064 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA80_RS02325 (MUA80_02320) 480379..481920 + 1542 WP_000424963.1 glutamine-hydrolyzing GMP synthase -
MUA80_RS02330 (MUA80_02325) 482014..483150 - 1137 WP_045178614.1 site-specific integrase -
MUA80_RS02335 (MUA80_02330) 483234..484019 - 786 WP_045178615.1 helix-turn-helix transcriptional regulator -
MUA80_RS02340 (MUA80_02335) 484136..484363 + 228 WP_000494396.1 helix-turn-helix transcriptional regulator -
MUA80_RS02345 (MUA80_02340) 484409..484669 + 261 WP_000080597.1 hypothetical protein -
MUA80_RS02350 (MUA80_02345) 484716..484862 + 147 WP_172643983.1 hypothetical protein -
MUA80_RS02355 (MUA80_02350) 484855..485064 + 210 WP_045178617.1 hypothetical protein Antitoxin
MUA80_RS02360 (MUA80_02355) 485067..485393 + 327 WP_045178618.1 DUF1474 family protein Toxin
MUA80_RS02365 (MUA80_02360) 485458..486327 + 870 WP_045178619.1 primase alpha helix C-terminal domain-containing protein -
MUA80_RS02370 (MUA80_02365) 486344..487801 + 1458 WP_045178620.1 virulence-associated E family protein -
MUA80_RS02375 (MUA80_02370) 488102..488464 + 363 WP_045178622.1 hypothetical protein -
MUA80_RS02380 (MUA80_02375) 488466..488750 + 285 WP_045178623.1 hypothetical protein -
MUA80_RS02385 (MUA80_02380) 488747..489388 + 642 WP_045178624.1 pathogenicity island protein -
MUA80_RS02390 (MUA80_02385) 489905..490246 + 342 WP_001190600.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 477582..498934 21352


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 13165.42 Da        Isoelectric Point: 4.5527

>T240444 WP_045178618.1 NZ_CP094791:485067-485393 [Staphylococcus aureus]
MNWEINDLFSDLKVLKDRFEDLKDNHGWHFEELYPHEPNHNLNKDELIREGFSYHERRIHNNQMFDLFHLYIEQFDNIIE
KFHEIEKASSENFGEESDDAKNSIKVAE

Download         Length: 327 bp

>T240444 NZ_LS999560:c4498843-4498670 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTTCTGGTCGGAATAACCTGGCCAATGAGTTTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8237.34 Da        Isoelectric Point: 4.6311

>AT240444 WP_045178617.1 NZ_CP094791:484855-485064 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLKLSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Download         Length: 210 bp

>AT240444 NZ_LS999560:c4499167-4498871 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAGCATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References