Detailed information of TA system TA240443

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 449012..449550
• Replicon: chromosome
• Accession: NZ_CP094791
• Organism: Staphylococcus aureus strain IVB6166

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: -
• Locus tag: MUA80_RS02150
• Protein ID: WP_045178601.1
• Coordinates: 449224..449550 (+)
• Length: 109 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: -
• Locus tag: MUA80_RS02145
• Protein ID: WP_045178599.1
• Coordinates: 449012..449221 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA80_RS02110 (MUA80_02105)	445221..446141	-	921	Protein_419	tyrosine-type recombinase/integrase	-
MUA80_RS02115 (MUA80_02110)	446420..447049	-	630	WP_231858805.1	XRE family transcriptional regulator	-
MUA80_RS02120 (MUA80_02115)	447072..447596	-	525	Protein_421	SAP domain protein	-
MUA80_RS02125 (MUA80_02120)	447623..448195	-	573	WP_001186980.1	helix-turn-helix transcriptional regulator	-
MUA80_RS02130 (MUA80_02125)	448367..448588	+	222	WP_000560872.1	helix-turn-helix transcriptional regulator	-
MUA80_RS02135 (MUA80_02130)	448589..448861	+	273	WP_000124597.1	helix-turn-helix domain-containing protein	-
MUA80_RS02140 (MUA80_02135)	448873..449019	+	147	WP_000784893.1	hypothetical protein	-
MUA80_RS02145 (MUA80_02140)	449012..449221	+	210	WP_045178599.1	hypothetical protein	Antitoxin
MUA80_RS02150 (MUA80_02145)	449224..449550	+	327	WP_045178601.1	DUF1474 family protein	Toxin
MUA80_RS02155 (MUA80_02150)	449615..450484	+	870	WP_045178602.1	primase alpha helix C-terminal domain-containing protein	-
MUA80_RS02160 (MUA80_02155)	450498..452207	+	1710	Protein_429	DUF927 domain-containing protein	-
MUA80_RS02165 (MUA80_02160)	452518..452898	+	381	WP_000356932.1	hypothetical protein	-
MUA80_RS02170 (MUA80_02165)	452895..453536	+	642	WP_045178603.1	pathogenicity island protein	-
MUA80_RS02175 (MUA80_02170)	453884..454225	+	342	WP_001190600.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	437267..464105	26838

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-100)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 109 a.a.
• Molecular weight: 13093.44 Da
• Isoelectric Point: 4.6496

>T240443 WP_045178601.1 NZ_CP094791:449224-449550 [Staphylococcus aureus]
MNLEINDLFSDLKLLKDRFEDLKDSHGWHFEELYPHEPNHNLNKDELIREGFSYHERRIHNNQMFDLFHLYIEQFDKIIE
KFHEIEKASSENFGEESDDAKNSIKVAE

Nucleotide

• Length: 327 bp

>T240443 NZ_LS999560:c4395901-4395551 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8220.25 Da
• Isoelectric Point: 4.3718

>AT240443 WP_045178599.1 NZ_CP094791:449012-449221 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELILKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT240443 NZ_LS999560:c4396146-4395895 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA