Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2255529..2256043 Replicon chromosome
Accession NZ_CP094789
Organism Staphylococcus aureus strain IVB6167

Toxin (Protein)


Gene name TsdT Uniprot ID A0A7U7IDH9
Locus tag MUA09_RS11410 Protein ID WP_000581791.1
Coordinates 2255529..2255738 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag MUA09_RS11415 Protein ID WP_000138934.1
Coordinates 2255750..2256043 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA09_RS11390 (MUA09_11370) 2251418..2252488 - 1071 WP_000159638.1 D-alanine--D-alanine ligase -
MUA09_RS11395 (MUA09_11375) 2252806..2254008 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
MUA09_RS11400 (MUA09_11380) 2254169..2254852 - 684 Protein_2207 transposase -
MUA09_RS11405 (MUA09_11385) 2255264..2255401 - 138 WP_000828354.1 Lmo0850 family protein -
MUA09_RS11410 (MUA09_11390) 2255529..2255738 - 210 WP_000581791.1 heavy metal-associated domain-containing protein Toxin
MUA09_RS11415 (MUA09_11395) 2255750..2256043 - 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
MUA09_RS11420 (MUA09_11400) 2256209..2257693 + 1485 WP_000571560.1 cardiolipin synthase -
MUA09_RS11425 (MUA09_11405) 2257721..2258368 + 648 WP_001187612.1 HD domain-containing protein -
MUA09_RS11430 (MUA09_11410) 2258625..2258924 + 300 WP_001793952.1 hypothetical protein -
MUA09_RS11435 (MUA09_11415) 2259081..2259953 - 873 WP_000725802.1 membrane protein insertase YidC -
MUA09_RS11440 (MUA09_11420) 2260039..2260680 - 642 WP_045179393.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7826.83 Da        Isoelectric Point: 4.1008

>T240436 WP_000581791.1 NZ_CP094789:c2255738-2255529 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVIINIIDGQVTVAYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T240436 NZ_LS999560:c3624402-3624100 [Escherichia coli]
ATGGCTCAAAAGAAAAATATAAGGAGTTTTCGTGATGCCTGGTTGGCTGATTTTTTTGTCCATTCAACGCCACATCGAAA
GATCCCTGCTGAAATCCATACCACGTTATCACGAAAGTTGGACATCATTAATGCTGCCACTTCTCATCGGGATTTACGCT
CCCCTCCGGGGAACCGATACGAAGAGTTATCCGGGAAATTACAGGAATACTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATTTTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTTTTTAGACCCACACAACTACTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT240436 WP_000138934.1 NZ_CP094789:c2256043-2255750 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT240436 NZ_LS999560:c3624064-3623723 [Escherichia coli]
ATGAAACAGGCAACAAGAAAACCGACGACACCCGGAGATATTCTTCTCTATGAATATCTGGAACCGCTCGATTTGAAAAT
CAATGAGTTAGCAGAGTTGCTGCATGTTCATCGTAATAGCGTCAGTGCACTGATCAATAACAATCGTAAACTCACCACTG
AGATGGCATTCCGTCTGGCGAAAGTTTTTGATACCACAGTCGATTTTTGGCTAAACCTCCAGGCGGCAGTTGATCTTTGG
GAAGTTGAAAACAACATGCGTACCCAGGAAGAATTGGGACGGATTGAAACAGTGGCTGAATATTTGGCACGCCGTGAAGA
GCGTGCAAAAAAGGTCGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7IDH9

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References