Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2234793..2235322 Replicon chromosome
Accession NZ_CP094789
Organism Staphylococcus aureus strain IVB6167

Toxin (Protein)


Gene name mazF Uniprot ID Q6GF05
Locus tag MUA09_RS11315 Protein ID WP_000621176.1
Coordinates 2234793..2235155 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag MUA09_RS11320 Protein ID WP_000948331.1
Coordinates 2235152..2235322 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA09_RS11295 (MUA09_11275) 2231771..2232541 - 771 WP_001041107.1 RNA polymerase sigma factor SigB -
MUA09_RS11300 (MUA09_11280) 2232516..2232995 - 480 WP_001190825.1 anti-sigma B factor RsbW -
MUA09_RS11305 (MUA09_11285) 2232997..2233323 - 327 WP_001052491.1 anti-sigma factor antagonist -
MUA09_RS11310 (MUA09_11290) 2233442..2234443 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
MUA09_RS11315 (MUA09_11295) 2234793..2235155 - 363 WP_000621176.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MUA09_RS11320 (MUA09_11300) 2235152..2235322 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
MUA09_RS11325 (MUA09_11305) 2235407..2236555 - 1149 WP_001281140.1 alanine racemase -
MUA09_RS11330 (MUA09_11310) 2236621..2236980 - 360 WP_000581197.1 holo-ACP synthase -
MUA09_RS11335 (MUA09_11315) 2236984..2237475 - 492 WP_001286801.1 PH domain-containing protein -
MUA09_RS11340 (MUA09_11320) 2237468..2239045 - 1578 Protein_2195 PH domain-containing protein -
MUA09_RS11345 (MUA09_11325) 2239038..2239517 - 480 WP_001287082.1 hypothetical protein -
MUA09_RS11350 (MUA09_11330) 2239726..2240286 - 561 WP_001092414.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13469.74 Da        Isoelectric Point: 10.1654

>T240435 WP_000621176.1 NZ_CP094789:c2235155-2234793 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVVHQKN

Download         Length: 363 bp

>T240435 NZ_LS999560:2773281-2773388 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACAACCTGGCGGCACCGATCCTGGCGGGGATTATTACCGCAGTGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT240435 WP_000948331.1 NZ_CP094789:c2235322-2235152 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp

>AT240435 NZ_LS999560:c2773224-2773169 [Escherichia coli]
CAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A168PYX0

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References