Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_XRE(antitoxin)
Location 1695376..1696173 Replicon chromosome
Accession NZ_CP094789
Organism Staphylococcus aureus strain IVB6167

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag MUA09_RS08495 Protein ID WP_045179173.1
Coordinates 1695712..1696173 (+) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag MUA09_RS08490 Protein ID WP_045179171.1
Coordinates 1695376..1695699 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA09_RS08405 (MUA09_08385) 1690513..1690776 - 264 WP_246864366.1 hypothetical protein -
MUA09_RS08410 (MUA09_08390) 1690777..1690944 - 168 WP_045178556.1 DUF1270 domain-containing protein -
MUA09_RS08415 (MUA09_08395) 1690928..1691074 - 147 WP_000230000.1 hypothetical protein -
MUA09_RS08420 (MUA09_08400) 1691124..1691336 + 213 WP_000461464.1 hypothetical protein -
MUA09_RS08425 (MUA09_08405) 1691351..1691428 - 78 Protein_1656 hypothetical protein -
MUA09_RS08430 (MUA09_08410) 1691441..1691704 - 264 WP_031880120.1 helix-turn-helix domain-containing protein -
MUA09_RS08435 (MUA09_08415) 1691854..1691952 - 99 Protein_1658 hypothetical protein -
MUA09_RS08440 (MUA09_08420) 1691949..1692275 - 327 WP_001025595.1 hypothetical protein -
MUA09_RS08445 (MUA09_08425) 1692602..1692841 - 240 WP_001294156.1 hypothetical protein -
MUA09_RS08450 (MUA09_08430) 1692901..1693128 + 228 WP_000801108.1 hypothetical protein -
MUA09_RS08455 (MUA09_08435) 1693130..1693321 - 192 WP_000389906.1 hypothetical protein -
MUA09_RS08460 (MUA09_08440) 1693378..1693587 + 210 WP_000772137.1 hypothetical protein -
MUA09_RS08465 (MUA09_08445) 1693580..1693720 - 141 WP_000939495.1 hypothetical protein -
MUA09_RS08470 (MUA09_08450) 1693736..1694488 - 753 WP_262543753.1 phage antirepressor KilAC domain-containing protein -
MUA09_RS08475 (MUA09_08455) 1694545..1694775 + 231 WP_045179168.1 hypothetical protein -
MUA09_RS08480 (MUA09_08460) 1694772..1694948 - 177 WP_001001356.1 hypothetical protein -
MUA09_RS08485 (MUA09_08465) 1694964..1695212 - 249 WP_000272859.1 helix-turn-helix transcriptional regulator -
MUA09_RS08490 (MUA09_08470) 1695376..1695699 + 324 WP_045179171.1 helix-turn-helix transcriptional regulator Antitoxin
MUA09_RS08495 (MUA09_08475) 1695712..1696173 + 462 WP_045179173.1 toxin Toxin
MUA09_RS08500 (MUA09_08480) 1696190..1696622 + 433 Protein_1671 hypothetical protein -
MUA09_RS08505 (MUA09_08485) 1696651..1697046 + 396 WP_001558060.1 hypothetical protein -
MUA09_RS08510 (MUA09_08490) 1697135..1697281 + 147 WP_001795334.1 hypothetical protein -
MUA09_RS08515 (MUA09_08495) 1697278..1697892 - 615 WP_000191466.1 hypothetical protein -
MUA09_RS08520 (MUA09_08500) 1698018..1699223 + 1206 WP_045179176.1 tyrosine-type recombinase/integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - sak / sea 1653657..1711998 58341


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(8-65)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 18054.43 Da        Isoelectric Point: 4.6899

>T240431 WP_045179173.1 NZ_CP094789:1695712-1696173 [Staphylococcus aureus]
MGLYEETLIQHDYIEVREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSIFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEHYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Download         Length: 462 bp

>T240431 NZ_LS999560:1886046-1886300 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAGCAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAACTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCTTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12489.13 Da        Isoelectric Point: 8.4338

>AT240431 WP_045179171.1 NZ_CP094789:1695376-1695699 [Staphylococcus aureus]
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANELKVTPEYLLLKNRQTENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK

Download         Length: 324 bp

>AT240431 NZ_LS999560:1885798-1886049 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGACAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References