Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | parDE/- |
Location | 2012453..2012982 | Replicon | chromosome |
Accession | NC_012943 | ||
Organism | Mycobacterium tuberculosis KZN 1435 |
Toxin (Protein)
Gene name | parE | Uniprot ID | G0TMR4 |
Locus tag | TBMG_RS09590 | Protein ID | WP_003411124.1 |
Coordinates | 2012665..2012982 (+) | Length | 106 a.a. |
Antitoxin (Protein)
Gene name | parD | Uniprot ID | P9WJ74 |
Locus tag | TBMG_RS09585 | Protein ID | WP_003411127.1 |
Coordinates | 2012453..2012668 (+) | Length | 72 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
TBMG_RS09555 | 2007559..2008335 | + | 777 | WP_003411137.1 | YggS family pyridoxal phosphate-dependent enzyme | - |
TBMG_RS09560 | 2008401..2009057 | + | 657 | WP_003411133.1 | cell division protein SepF | - |
TBMG_RS09565 | 2009219..2009509 | + | 291 | WP_003900476.1 | YggT family protein | - |
TBMG_RS09570 | 2009777..2010559 | + | 783 | WP_003411131.1 | cell wall synthesis protein Wag31 | - |
TBMG_RS09575 | 2010654..2011010 | + | 357 | WP_003411130.1 | hypothetical protein | - |
TBMG_RS09580 | 2011140..2012198 | - | 1059 | WP_003411129.1 | hypothetical protein | - |
TBMG_RS09585 | 2012453..2012668 | + | 216 | WP_003411127.1 | antitoxin ParD2 | Antitoxin |
TBMG_RS09590 | 2012665..2012982 | + | 318 | WP_003411124.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
TBMG_RS09600 | 2013395..2014741 | + | 1347 | WP_003411121.1 | M20/M25/M40 family metallo-hydrolase | - |
TBMG_RS09605 | 2014789..2015319 | + | 531 | WP_003411119.1 | YbhB/YbcL family Raf kinase inhibitor-like protein | - |
TBMG_RS09610 | 2015324..2016397 | - | 1074 | WP_003411116.1 | quinone-dependent dihydroorotate dehydrogenase | - |
TBMG_RS09615 | 2016433..2016714 | - | 282 | WP_003411112.1 | hypothetical protein | - |
TBMG_RS09620 | 2016711..2017787 | - | 1077 | WP_003411110.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 106 a.a. Molecular weight: 12312.88 Da Isoelectric Point: 6.4831
>T24043 WP_003411124.1 NC_012943:2012665-2012982 [Mycobacterium tuberculosis KZN 1435]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE
Download Length: 318 bp
>T24043 NC_012943:2012665-2012982 [Mycobacterium tuberculosis KZN 1435]
ATGACGCGCAGGCTGCGCGTCCATAACGGGGTTGAAGACGACCTATTCGAGGCGTTTTCCTACTACGCGGACGCGGCGCC
AGATCAGATCGATCGGCTTTACAACTTGTTTGTCGATGCCGTGACGAAGCGGATTCCGCAGGCTCCGAACGCGTTTGCGC
CGTTATTCAAGCACTATCGACACATCTACCTCCGGCCCTTCAGGTACTACGTTGCCTATCGGACGACCGACGAGGCTATC
GACATACTGGCTGTTCGGCACGGAATGGAGAACCCGAACGCGGTCGAGGCTGAGATCTCTGGCCGCACCTTCGAGTGA
ATGACGCGCAGGCTGCGCGTCCATAACGGGGTTGAAGACGACCTATTCGAGGCGTTTTCCTACTACGCGGACGCGGCGCC
AGATCAGATCGATCGGCTTTACAACTTGTTTGTCGATGCCGTGACGAAGCGGATTCCGCAGGCTCCGAACGCGTTTGCGC
CGTTATTCAAGCACTATCGACACATCTACCTCCGGCCCTTCAGGTACTACGTTGCCTATCGGACGACCGACGAGGCTATC
GACATACTGGCTGTTCGGCACGGAATGGAGAACCCGAACGCGGTCGAGGCTGAGATCTCTGGCCGCACCTTCGAGTGA
Antitoxin
Download Length: 72 a.a. Molecular weight: 7880.70 Da Isoelectric Point: 4.4055
>AT24043 WP_003411127.1 NC_012943:2012453-2012668 [Mycobacterium tuberculosis KZN 1435]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG
Download Length: 216 bp
>AT24043 NC_012943:2012453-2012668 [Mycobacterium tuberculosis KZN 1435]
GTGGTGGTCAACCGGGCATTGCTGGCGAGCGTCGACGCACTGTCGCGTGATGAGCAGATTGAGCTCGTCGAGCACATCAA
CGGAAACCTAGCCGAGGGCATGCATATCAGCGAGGCCAACCAGGCGCTCATCGAAGCGCGGGCCAATGACACCGACGATG
CTCATTGGTCCACCATTGATGACTTCGACAAGCGGATCCGCGCCCGGCTCGGATGA
GTGGTGGTCAACCGGGCATTGCTGGCGAGCGTCGACGCACTGTCGCGTGATGAGCAGATTGAGCTCGTCGAGCACATCAA
CGGAAACCTAGCCGAGGGCATGCATATCAGCGAGGCCAACCAGGCGCTCATCGAAGCGCGGGCCAATGACACCGACGATG
CTCATTGGTCCACCATTGATGACTTCGACAAGCGGATCCGCGCCCGGCTCGGATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | G0TMR4 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U4FAJ4 |