Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/-
Location 2012453..2012982 Replicon chromosome
Accession NC_012943
Organism Mycobacterium tuberculosis KZN 1435

Toxin (Protein)


Gene name parE Uniprot ID G0TMR4
Locus tag TBMG_RS09590 Protein ID WP_003411124.1
Coordinates 2012665..2012982 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P9WJ74
Locus tag TBMG_RS09585 Protein ID WP_003411127.1
Coordinates 2012453..2012668 (+) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TBMG_RS09555 2007559..2008335 + 777 WP_003411137.1 YggS family pyridoxal phosphate-dependent enzyme -
TBMG_RS09560 2008401..2009057 + 657 WP_003411133.1 cell division protein SepF -
TBMG_RS09565 2009219..2009509 + 291 WP_003900476.1 YggT family protein -
TBMG_RS09570 2009777..2010559 + 783 WP_003411131.1 cell wall synthesis protein Wag31 -
TBMG_RS09575 2010654..2011010 + 357 WP_003411130.1 hypothetical protein -
TBMG_RS09580 2011140..2012198 - 1059 WP_003411129.1 hypothetical protein -
TBMG_RS09585 2012453..2012668 + 216 WP_003411127.1 antitoxin ParD2 Antitoxin
TBMG_RS09590 2012665..2012982 + 318 WP_003411124.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
TBMG_RS09600 2013395..2014741 + 1347 WP_003411121.1 M20/M25/M40 family metallo-hydrolase -
TBMG_RS09605 2014789..2015319 + 531 WP_003411119.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
TBMG_RS09610 2015324..2016397 - 1074 WP_003411116.1 quinone-dependent dihydroorotate dehydrogenase -
TBMG_RS09615 2016433..2016714 - 282 WP_003411112.1 hypothetical protein -
TBMG_RS09620 2016711..2017787 - 1077 WP_003411110.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin

Conserved hypothetical protein CHP02574, addiction module

(11-69)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12312.88 Da        Isoelectric Point: 6.4831

>T24043 WP_003411124.1 NC_012943:2012665-2012982 [Mycobacterium tuberculosis KZN 1435]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Download         Length: 318 bp

>T24043 NC_012943:2012665-2012982 [Mycobacterium tuberculosis KZN 1435]
ATGACGCGCAGGCTGCGCGTCCATAACGGGGTTGAAGACGACCTATTCGAGGCGTTTTCCTACTACGCGGACGCGGCGCC
AGATCAGATCGATCGGCTTTACAACTTGTTTGTCGATGCCGTGACGAAGCGGATTCCGCAGGCTCCGAACGCGTTTGCGC
CGTTATTCAAGCACTATCGACACATCTACCTCCGGCCCTTCAGGTACTACGTTGCCTATCGGACGACCGACGAGGCTATC
GACATACTGGCTGTTCGGCACGGAATGGAGAACCCGAACGCGGTCGAGGCTGAGATCTCTGGCCGCACCTTCGAGTGA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7880.70 Da        Isoelectric Point: 4.4055

>AT24043 WP_003411127.1 NC_012943:2012453-2012668 [Mycobacterium tuberculosis KZN 1435]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Download         Length: 216 bp

>AT24043 NC_012943:2012453-2012668 [Mycobacterium tuberculosis KZN 1435]
GTGGTGGTCAACCGGGCATTGCTGGCGAGCGTCGACGCACTGTCGCGTGATGAGCAGATTGAGCTCGTCGAGCACATCAA
CGGAAACCTAGCCGAGGGCATGCATATCAGCGAGGCCAACCAGGCGCTCATCGAAGCGCGGGCCAATGACACCGACGATG
CTCATTGGTCCACCATTGATGACTTCGACAAGCGGATCCGCGCCCGGCTCGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TMR4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAJ4

References