Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TsaAT/- |
| Location | 934388..934865 | Replicon | chromosome |
| Accession | NZ_CP094789 | ||
| Organism | Staphylococcus aureus strain IVB6167 | ||
Toxin (Protein)
| Gene name | TsaT | Uniprot ID | T1Y7S2 |
| Locus tag | MUA09_RS04620 | Protein ID | WP_000052076.1 |
| Coordinates | 934388..934576 (-) | Length | 63 a.a. |
Antitoxin (Protein)
| Gene name | TsaA | Uniprot ID | T1Y6P8 |
| Locus tag | MUA09_RS04625 | Protein ID | WP_001059690.1 |
| Coordinates | 934605..934865 (-) | Length | 87 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MUA09_RS04590 (MUA09_04575) | 930341..930898 | + | 558 | WP_045178710.1 | hypothetical protein | - |
| MUA09_RS04595 (MUA09_04580) | 931239..931925 | + | 687 | WP_001574556.1 | thermonuclease family protein | - |
| MUA09_RS04600 (MUA09_04585) | 932282..932482 | + | 201 | WP_001059082.1 | cold-shock protein | - |
| MUA09_RS04605 (MUA09_04590) | 932979..933197 | - | 219 | WP_000005879.1 | hypothetical protein | - |
| MUA09_RS04610 (MUA09_04595) | 933259..933543 | - | 285 | WP_001004401.1 | hypothetical protein | - |
| MUA09_RS04615 (MUA09_04600) | 933631..934200 | - | 570 | WP_001106663.1 | lipoprotein N-acylation protein LnsA | - |
| MUA09_RS04620 (MUA09_04605) | 934388..934576 | - | 189 | WP_000052076.1 | hypothetical protein | Toxin |
| MUA09_RS04625 (MUA09_04610) | 934605..934865 | - | 261 | WP_001059690.1 | hypothetical protein | Antitoxin |
| MUA09_RS04630 (MUA09_04615) | 935206..935409 | + | 204 | WP_000145163.1 | sterile alpha motif-like domain-containing protein | - |
| MUA09_RS04635 (MUA09_04620) | 935406..935642 | - | 237 | WP_000368687.1 | hypothetical protein | - |
| MUA09_RS04640 (MUA09_04625) | 935866..936447 | + | 582 | WP_001140696.1 | histidine phosphatase family protein | - |
| MUA09_RS04645 (MUA09_04630) | 936520..937137 | - | 618 | WP_000255548.1 | LysE/ArgO family amino acid transporter | - |
| MUA09_RS04650 (MUA09_04635) | 937293..937787 | - | 495 | WP_000569884.1 | GNAT family N-acetyltransferase | - |
| MUA09_RS04655 (MUA09_04640) | 938186..938608 | - | 423 | WP_000974455.1 | organic hydroperoxide resistance protein | - |
| MUA09_RS04660 (MUA09_04645) | 938756..939472 | + | 717 | WP_000150025.1 | type I 3-dehydroquinate dehydratase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | tsst-1 / vWbp | 902228..940094 | 37866 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 63 a.a. Molecular weight: 7142.82 Da Isoelectric Point: 9.9971
>T240427 WP_000052076.1 NZ_CP094789:c934576-934388 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL
Download Length: 189 bp
>T240427 NZ_LS999560:641218-641532 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCTTCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTCGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCCGTTCATCGTACTAAGGGGAAAAAATGA
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCTTCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTCGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCCGTTCATCGTACTAAGGGGAAAAAATGA
Antitoxin
Download Length: 87 a.a. Molecular weight: 9940.09 Da Isoelectric Point: 4.0624
>AT240427 WP_001059690.1 NZ_CP094789:c934865-934605 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG
Download Length: 261 bp
>AT240427 NZ_LS999560:641529-641945 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTACTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGTGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTTCCGGAAATAGGCAGTAAATCGATGGT
GTCACGCGTTTTGAGCGGGAAAAGGAAATTAACGCTGGAACACGCTAAAAAACTGGCAACGCGATTCGGTATTTCTCCCG
CCTTGTTTATTGATTAA
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTACTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGTGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTTCCGGAAATAGGCAGTAAATCGATGGT
GTCACGCGTTTTGAGCGGGAAAAGGAAATTAACGCTGGAACACGCTAAAAAACTGGCAACGCGATTCGGTATTTCTCCCG
CCTTGTTTATTGATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E0VP18 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E0VN56 |