Detailed information of TA system TA240426

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 484855..485393
• Replicon: chromosome
• Accession: NZ_CP094789
• Organism: Staphylococcus aureus strain IVB6167

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: -
• Locus tag: MUA09_RS02360
• Protein ID: WP_045178618.1
• Coordinates: 485067..485393 (+)
• Length: 109 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: -
• Locus tag: MUA09_RS02355
• Protein ID: WP_045178617.1
• Coordinates: 484855..485064 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA09_RS02325 (MUA09_02320)	480379..481920	+	1542	WP_000424963.1	glutamine-hydrolyzing GMP synthase	-
MUA09_RS02330 (MUA09_02325)	482014..483150	-	1137	WP_045178614.1	site-specific integrase	-
MUA09_RS02335 (MUA09_02330)	483234..484019	-	786	WP_045178615.1	helix-turn-helix transcriptional regulator	-
MUA09_RS02340 (MUA09_02335)	484136..484363	+	228	WP_000494396.1	helix-turn-helix transcriptional regulator	-
MUA09_RS02345 (MUA09_02340)	484409..484669	+	261	WP_000080597.1	hypothetical protein	-
MUA09_RS02350 (MUA09_02345)	484716..484862	+	147	WP_172643983.1	hypothetical protein	-
MUA09_RS02355 (MUA09_02350)	484855..485064	+	210	WP_045178617.1	hypothetical protein	Antitoxin
MUA09_RS02360 (MUA09_02355)	485067..485393	+	327	WP_045178618.1	DUF1474 family protein	Toxin
MUA09_RS02365 (MUA09_02360)	485458..486327	+	870	WP_045178619.1	primase alpha helix C-terminal domain-containing protein	-
MUA09_RS02370 (MUA09_02365)	486344..487801	+	1458	WP_045178620.1	virulence-associated E family protein	-
MUA09_RS02375 (MUA09_02370)	488102..488464	+	363	WP_045178622.1	hypothetical protein	-
MUA09_RS02380 (MUA09_02375)	488466..488750	+	285	WP_045178623.1	hypothetical protein	-
MUA09_RS02385 (MUA09_02380)	488747..489388	+	642	WP_045178624.1	pathogenicity island protein	-
MUA09_RS02390 (MUA09_02385)	489905..490246	+	342	WP_001190600.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	477582..498934	21352

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-100)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 109 a.a.
• Molecular weight: 13165.42 Da
• Isoelectric Point: 4.5527

>T240426 WP_045178618.1 NZ_CP094789:485067-485393 [Staphylococcus aureus]
MNWEINDLFSDLKVLKDRFEDLKDNHGWHFEELYPHEPNHNLNKDELIREGFSYHERRIHNNQMFDLFHLYIEQFDNIIE
KFHEIEKASSENFGEESDDAKNSIKVAE

Nucleotide

• Length: 327 bp

>T240426 NZ_LS999560:c599902-599438 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTAGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8237.34 Da
• Isoelectric Point: 4.6311

>AT240426 WP_045178617.1 NZ_CP094789:484855-485064 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLKLSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT240426 NZ_LS999560:c600237-599902 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTAACGCTGTACTGACCACTGAATCAAAGGTCACTATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCTGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAT
CCGCAAAAAACTCGTCCATTCGACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGACGATGAGAT
TGGCGACGACGAATAA