240420

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2112974..2113488 Replicon chromosome
Accession NZ_CP094787
Organism Staphylococcus aureus strain IVB6168

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag MUA13_RS10370 Protein ID WP_000581792.1
Coordinates 2112974..2113183 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag MUA13_RS10375 Protein ID WP_000138932.1
Coordinates 2113195..2113488 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA13_RS10350 (MUA13_10340) 2108482..2109840 - 1359 WP_262522431.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
MUA13_RS10355 (MUA13_10345) 2109855..2110925 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
MUA13_RS10360 (MUA13_10350) 2111243..2112445 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
MUA13_RS10365 (MUA13_10355) 2112709..2112846 - 138 WP_000828354.1 Lmo0850 family protein -
MUA13_RS10370 (MUA13_10360) 2112974..2113183 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
MUA13_RS10375 (MUA13_10365) 2113195..2113488 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
MUA13_RS10380 (MUA13_10370) 2113654..2115138 + 1485 WP_000571549.1 cardiolipin synthase -
MUA13_RS10385 (MUA13_10375) 2115166..2115813 + 648 WP_001187629.1 HD domain-containing protein -
MUA13_RS10390 (MUA13_10380) 2116627..2117499 - 873 WP_000725802.1 membrane protein insertase YidC -
MUA13_RS10395 (MUA13_10385) 2117585..2118226 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T240420 WP_000581792.1 NZ_CP094787:c2113183-2112974 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T240420 NZ_LS999206:c4776312-4775941 [Enterobacter hormaechei]
ATGGAGCACATGGCAGTGTTTGATACCAATATTCTCATTGATCTCTTCAACAACCGTATTGAAGCTGCGGATGCGATTGA
GCATACCGCGTCGCATCGTGCCATCAGCTTAATTACCTGGATGGAAGTAATGGTGGGCGCTCGCAGGCATGGTCATGAAG
CGAAAACGGCAGCCGTTATGGGCGCTTTTGAAATTATTGATGTGTCTCGGGATATTGCGGAAAGAAGCGTTTTACTACGT
GAGAAGCATGGAATGAAACTGCCTGATGCTATCATTCTGGCCACAGCGCAGAGCAGAAAATGTCCGTTGATTTCTCGCAA
CACGAAAGATTTTGCGGGTATTGACGAGGTCCTTACGCCTTACCAGGTGTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT240420 WP_000138932.1 NZ_CP094787:c2113488-2113195 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT240420 NZ_LS999206:c4776557-4776315 [Enterobacter hormaechei]
ATGAGCGTTTTGGCGGAACTTGATATGGGCAGAATACTTATCGATTTGTCTGATGACGTGATTCAACGTTTGGATAATCT
CAAGCAATTGCGAAATCAACCACGTGCTGAACTGCTTCGGGAAGCGATAGAACTGTATCTCGACCAGCAGAGTTCTTCTG
TTATCCGAAATGCGCTTGGTCTGTGGGGAGACAGAAAAGAGGACGGGCTTGAGTATGAACGCAAGCTGCGTGAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References