Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1605079..1605731 Replicon chromosome
Accession NC_012943
Organism Mycobacterium tuberculosis KZN 1435

Toxin (Protein)


Gene name vapC Uniprot ID G0TPX1
Locus tag TBMG_RS07685 Protein ID WP_003412752.1
Coordinates 1605079..1605504 (-) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ24
Locus tag TBMG_RS07690 Protein ID WP_003412749.1
Coordinates 1605510..1605731 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TBMG_RS07660 1600084..1600641 + 558 WP_003412768.1 MaoC family dehydratase -
TBMG_RS07665 1600638..1601459 + 822 WP_003412766.1 citrate (pro-3S)-lyase subunit beta -
TBMG_RS07670 1601718..1602821 + 1104 WP_003412761.1 pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha -
TBMG_RS07675 1602832..1603878 + 1047 WP_003412757.1 3-methyl-2-oxobutanoate dehydrogenase subunit beta -
TBMG_RS07680 1603875..1605056 + 1182 WP_003899351.1 2-oxo acid dehydrogenase subunit E2 -
TBMG_RS07685 1605079..1605504 - 426 WP_003412752.1 type II toxin-antitoxin system VapC family toxin Toxin
TBMG_RS07690 1605510..1605731 - 222 WP_003412749.1 antitoxin Antitoxin
TBMG_RS07705 1607298..1607894 - 597 Protein_1514 hypothetical protein -
TBMG_RS07710 1607884..1608507 - 624 WP_003900858.1 TIGR00725 family protein -
TBMG_RS07715 1608643..1608849 + 207 WP_003899347.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1605986..1606870 884


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15392.89 Da        Isoelectric Point: 9.2386

>T24042 WP_003412752.1 NC_012943:c1605504-1605079 [Mycobacterium tuberculosis KZN 1435]
VALLDVNALVALAWDSHIHHARIREWFTANATLGWATCPLTEAGFVRVSTNPKVLPSAIGIADARRVLVALRAVGGHRFL
ADDVSLVDDDVPLIVGYRQVTDAHLLTLARRRGVRLVTFDAGVFTLAQQRPKTPVELLTIL

Download         Length: 426 bp

>T24042 NC_012943:c1605504-1605079 [Mycobacterium tuberculosis KZN 1435]
GTGGCGCTGCTCGACGTCAACGCATTGGTCGCGCTGGCGTGGGACTCACACATCCACCACGCCCGGATCCGCGAGTGGTT
TACCGCCAACGCCACGCTCGGCTGGGCGACTTGCCCGCTCACCGAAGCCGGCTTCGTGCGGGTGTCGACGAACCCAAAAG
TACTTCCTAGCGCGATCGGGATCGCAGACGCTCGACGGGTCCTCGTGGCACTACGCGCCGTGGGAGGCCACCGCTTCCTG
GCTGACGACGTATCGCTCGTCGATGACGATGTTCCGTTGATCGTCGGTTATCGCCAGGTGACCGACGCCCATCTGCTGAC
ACTCGCCCGCCGGCGCGGCGTCCGCCTGGTCACCTTCGACGCCGGTGTCTTCACCCTCGCCCAACAACGCCCCAAGACGC
CAGTGGAGCTGCTGACCATCCTCTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 7864.93 Da        Isoelectric Point: 4.5258

>AT24042 WP_003412749.1 NC_012943:c1605731-1605510 [Mycobacterium tuberculosis KZN 1435]
VRTTLDLDDDVIAAARELASSQRRSLGSVISELARRGLMPGRVEADDGLPVIRVPAGTPPITPEMVRRALDED

Download         Length: 222 bp

>AT24042 NC_012943:c1605731-1605510 [Mycobacterium tuberculosis KZN 1435]
GTGCGAACGACACTTGACCTTGACGACGATGTGATCGCCGCGGCACGTGAACTTGCCTCCAGCCAGCGCCGCTCGCTCGG
CTCGGTGATTTCCGAACTCGCACGCCGTGGTCTCATGCCCGGACGCGTCGAGGCTGACGACGGGCTGCCGGTGATCCGCG
TTCCAGCCGGGACCCCGCCGATCACACCGGAGATGGTCCGTCGCGCGCTCGATGAGGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TPX1

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BW03

References