Detailed information of TA system TA240419

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 2093216..2093745
• Replicon: chromosome
• Accession: NZ_CP094787
• Organism: Staphylococcus aureus strain IVB6168

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: MUA13_RS10280
• Protein ID: WP_000621175.1
• Coordinates: 2093216..2093578 (-)
• Length: 121 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: T1YCG8
• Locus tag: MUA13_RS10285
• Protein ID: WP_000948331.1
• Coordinates: 2093575..2093745 (-)
• Length: 57 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA13_RS10260 (MUA13_10250)	2090195..2090965	-	771	WP_001041108.1	RNA polymerase sigma factor SigB	-
MUA13_RS10265 (MUA13_10255)	2090940..2091419	-	480	WP_001190829.1	anti-sigma B factor RsbW	-
MUA13_RS10270 (MUA13_10260)	2091421..2091747	-	327	WP_001052491.1	anti-sigma factor antagonist	-
MUA13_RS10275 (MUA13_10265)	2091866..2092867	-	1002	WP_000390829.1	PP2C family protein-serine/threonine phosphatase	-
MUA13_RS10280 (MUA13_10270)	2093216..2093578	-	363	WP_000621175.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
MUA13_RS10285 (MUA13_10275)	2093575..2093745	-	171	WP_000948331.1	type II toxin-antitoxin system antitoxin MazE	Antitoxin
MUA13_RS10290 (MUA13_10280)	2093830..2094978	-	1149	WP_252570666.1	alanine racemase	-
MUA13_RS10295 (MUA13_10285)	2095044..2095403	-	360	WP_061838820.1	holo-ACP synthase	-
MUA13_RS10300 (MUA13_10290)	2095407..2095898	-	492	WP_001205910.1	PH domain-containing protein	-
MUA13_RS10305 (MUA13_10295)	2095885..2097468	-	1584	WP_001294626.1	PH domain-containing protein	-
MUA13_RS10310 (MUA13_10300)	2097461..2097940	-	480	WP_252570667.1	hypothetical protein	-
MUA13_RS10315 (MUA13_10305)	2098149..2098709	-	561	WP_252570668.1	K(+)-transporting ATPase subunit C	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-110)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 121 a.a.
• Molecular weight: 13441.69 Da
• Isoelectric Point: 10.1654

>T240419 WP_000621175.1 NZ_CP094787:c2093578-2093216 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Nucleotide

• Length: 363 bp

>T240419 NZ_LS999206:c3950365-3949955 [Enterobacter hormaechei]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCACAGTGGATGTCCTTACTGCTCCACGGGCTGGTGGCGGC
ACTGGTGTTATTGGTGCCGTGGCCGCTTAGCTATACCCCTCTGTGGTTGCTATTGCTGTCGTTTGTGGTGTTTGACAGCG
TGCGCAGCCAGCGTCGAATCAACGCCCGTCAGGGGGAAATTAAGCTGCTGATGGATTCTCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAGATGATGGGGACGCCGTGGATGCTTAATACCGGGATGATGCTACGGCTGCGTCGGGTCGAGGATAACCGTCG
CCAGCACCTGTGGCTGGCCGCAGACAGTATGGATCCCGCGGAGTGGCGAGATCTGCGCCGGTTGATCGTGCAACAGCCGA
CGCAGGAGTAA

Antitoxin

Protein

• Length: 57 a.a.
• Molecular weight: 6251.78 Da
• Isoelectric Point: 3.8305

>AT240419 WP_000948331.1 NZ_CP094787:c2093745-2093575 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Nucleotide

• Length: 171 bp

>AT240419 NZ_LS999206:c3950612-3950346 [Enterobacter hormaechei]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTCGAGTATGAGTACGACAGCTTAAGCGATGACGATAAGCGCCTGTTTGTCCGTCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A0E0VRZ1