Detailed information of TA system TA240418

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 2040385..2040917
• Replicon: chromosome
• Accession: NZ_CP094787
• Organism: Staphylococcus aureus strain IVB6168

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: -
• Locus tag: MUA13_RS10000
• Protein ID: WP_262522400.1
• Coordinates: 2040385..2040705 (-)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: -
• Locus tag: MUA13_RS10005
• Protein ID: WP_262522402.1
• Coordinates: 2040708..2040917 (-)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA13_RS09975 (MUA13_09965)	2035868..2036101	-	234	WP_252602655.1	hypothetical protein	-
MUA13_RS09980 (MUA13_09970)	2036115..2036456	-	342	WP_001190614.1	hypothetical protein	-
MUA13_RS09985 (MUA13_09975)	2036804..2037445	-	642	WP_262522399.1	pathogenicity island protein	-
MUA13_RS09990 (MUA13_09980)	2037447..2037791	-	345	WP_000567971.1	hypothetical protein	-
MUA13_RS09995 (MUA13_09985)	2038062..2040314	-	2253	WP_063650261.1	phage/plasmid primase, P4 family	-
MUA13_RS10000 (MUA13_09990)	2040385..2040705	-	321	WP_262522400.1	DUF1474 family protein	Toxin
MUA13_RS10005 (MUA13_09995)	2040708..2040917	-	210	WP_262522402.1	pathogenicity island protein	Antitoxin
MUA13_RS10010 (MUA13_10000)	2040910..2041056	-	147	WP_262522404.1	pathogenicity island protein	-
MUA13_RS10015 (MUA13_10005)	2041053..2041370	-	318	WP_262522406.1	helix-turn-helix domain-containing protein	-
MUA13_RS10020 (MUA13_10010)	2041384..2042025	-	642	WP_262522408.1	Bro-N domain-containing protein	-
MUA13_RS10025 (MUA13_10015)	2042029..2042241	-	213	WP_262522410.1	helix-turn-helix transcriptional regulator	-
MUA13_RS10030 (MUA13_10020)	2042395..2043057	+	663	WP_262522412.1	helix-turn-helix transcriptional regulator	-
MUA13_RS10035 (MUA13_10025)	2043070..2044242	+	1173	WP_262522414.1	site-specific integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	groEL	2023562..2046287	22725

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-100)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12820.24 Da
• Isoelectric Point: 5.4934

>T240418 WP_262522400.1 NZ_CP094787:c2040705-2040385 [Staphylococcus aureus]
MNWEINDLFSDLKVLKDRFEDLKDNHGWHFDNFYPHEPNHVLNKTEAIKEGLSYHERRIHNNQMFDLFHLYIEQFDKIIE
KFHEIEKASSENFGEVSDDAKNVKKA

Nucleotide

• Length: 321 bp

>T240418 NZ_LS999206:3722049-3722348 [Enterobacter hormaechei]
ATGATTAATCATTTTCGGGATCAATGGCTTGAGGATTTTTTTCTCTACGGGAGATCGAGCAATGTTATCCCTTTGAATCT
GGAAACAGCGCTTGCAAGAAAGCTCGACATCATCAATGCGGCCATGTCGCACCTGGATTTACGATCGCCACCGGGCAATA
TGTATGAAGCATTGAGTCCTCCGTTGAAGGGATATTCCTCTATCCGGGTAAACAGACAATACAGGCTTGTATTTCGCTGG
TCAGAGGGAAAAGCAGACGATCTCTATCTCTCTCCACACAAGTACACGCAACACAAGTGA

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8238.28 Da
• Isoelectric Point: 4.3718

>AT240418 WP_262522402.1 NZ_CP094787:c2040917-2040708 [Staphylococcus aureus]
MNNEQKEVLEHVVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT240418 NZ_LS999206:3722359-3722724 [Enterobacter hormaechei]
ATGACACTTCAACAGGCACTCCGCAAACCCACCACGCCGGGCGAGGTGTTGCAGTATGAGTATCTTGAACCGCTCAATCT
GAAAATCAACGATCTGGCAGAGATGCTAAATGTACACCGCAATACCGTAAGCGCATTGGTCAATAACAATCGCAAACTTA
CTGCCGATATGGCGATCAAACTGGCAAAAGCCTTTAATACCACTATTGAATTTTGGCTGAACTTACAGCTAAACGTTGAT
ATCTGGGAAGCGCAATCTAACTCCCGCACGCAGGAGGAGTTAAGCCGGATAAAAACCGTTGCGGAAGTCATGGCGAAGCG
AAAATCCGGCAAGCCAGACGTTACCCTGCACGGGAACAGCGCATAA